Igfbp5 insulin-like growth factor binding protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igfbp5provided by MGI
Official Full Name: insulin-like growth factor binding protein 5provided by MGI
Primary source: MGI:MGI:96440
See related: Ensembl:ENSMUSG00000026185 AllianceGenome:MGI:96440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IGFBP-5; IGFBP-5P
Summary: Enables fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including female pregnancy; lung alveolus development; and negative regulation of skeletal muscle hypertrophy. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of osteoblast differentiation; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; impulse conducting system; limb; and metanephros. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 121.4), kidney adult (RPKM 105.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C3; 1 36.94 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (72897224..72914024, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (72858065..72874865, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution.
Title: Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution.
CCCTC-Binding Factor Mediates the Transcription of Insulin-Like Growth Factor Binding Protein 5 Through EZH2 in Ulcerative Colitis.
Title: CCCTC-Binding Factor Mediates the Transcription of Insulin-Like Growth Factor Binding Protein 5 Through EZH2 in Ulcerative Colitis.
Insulin-binding protein-5 down-regulates the balance of Th17/Treg.
Title: Insulin-binding protein-5 down-regulates the balance of Th17/Treg.
IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.
Title: IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.
IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease.
Title: IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease.
Downregulation of PAPP-A2 expression or upregulation of IGFBP-5 expression can reduce collagen synthesis and cartilage proliferation. PAPP-A2 may be involved in the development of the hip joint by interfering in the fibrous and cartilaginous metabolism via IGF pathway-associated proteins pathway.
Title: Abnormal expression of Pappa2 gene may indirectly affect mouse hip development through the IGF signaling pathway.
Data demonstrate that dysregulation of miR-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function.
Title: Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration.
proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R inhibitors
Title: Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling.
Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression
Title: Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.
IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Title: The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:526859

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:471316

PMC85624P4 (e-PCR)
- UniSTS:273484

D1Mit281 (e-PCR), detects polymorphism
- UniSTS:128634

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:143490

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:461979

RH136081 (e-PCR)
- UniSTS:210076

NoName (e-PCR)
- UniSTS:224179

AW208790 (e-PCR)
- UniSTS:178410

D9Wox32 (e-PCR)
- UniSTS:240381

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor I binding	TAS Traceable Author Statement more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of skeletal muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type B pancreatic cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin-like growth factor binding protein complex	IC Inferred by Curator more info	PubMed
part_of insulin-like growth factor ternary complex	ISO Inferred from Sequence Orthology more info
part_of insulin-like growth factor ternary complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 5

Names: IBP-5; IGF-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010518.2 → NP_034648.2 insulin-like growth factor-binding protein 5 precursor

See identical proteins and their annotated locations for NP_034648.2

Status: VALIDATED

Source sequence(s)

BC018579, BC029321, BC057447

Consensus CDS

CCDS15037.1

UniProtKB/Swiss-Prot

Q07079

UniProtKB/TrEMBL

Q3UQV0

Related

ENSMUSP00000027377.9, ENSMUST00000027377.9

Conserved Domains (2) summary

smart00121
Location:24 → 100

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:191 → 262

Thyroglobulin_1; Thyroglobulin type-1 repeat