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Ifrd2 interferon-related developmental regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 15983, updated on 5-Mar-2024

Summary

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Official Symbol
Ifrd2provided by MGI
Official Full Name
interferon-related developmental regulator 2provided by MGI
Primary source
MGI:MGI:1316708
See related
Ensembl:ENSMUSG00000010048 AllianceGenome:MGI:1316708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SKMc15; 1810034A24Rik
Summary
Is expressed in several structures, including alimentary system; blood; embryo mesenchyme; extraembryonic component; and neural ectoderm. Orthologous to human IFRD2 (interferon related developmental regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 78.8), liver E14 (RPKM 68.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ifrd2 in Genome Data Viewer
Location:
9 F1; 9 58.24 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107464917..107470237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107587718..107593038)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2 Neighboring gene STARR-seq mESC enhancer starr_25176 Neighboring gene hyaluronoglucosaminidase 1 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E300 Neighboring gene hyaluronoglucosaminidase 3 Neighboring gene leucine-rich single-pass membrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11753 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Neighboring gene STARR-positive B cell enhancer ABC_E8314 Neighboring gene G protein subunit alpha i2 Neighboring gene predicted gene, 53518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes. Buanne P, et al. Genomics, 1998 Jul 15. PMID 9722946
  2. Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX? Jadin L, et al. FASEB J, 2008 Dec. PMID 18772348
  3. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. Shuttleworth TL, et al. J Biol Chem, 2002 Jun 21. PMID 11929860
  4. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Lerman MI, et al. Cancer Res, 2000 Nov 1. PMID 11085536
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
    Title: The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables translation repressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interferon-related developmental regulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025903.2 → NP_080179.1  interferon-related developmental regulator 2

    See identical proteins and their annotated locations for NP_080179.1

    Status: PROVISIONAL

    Source sequence(s)
    AK007687
    Consensus CDS
    CCDS23500.1
    UniProtKB/Swiss-Prot
    Q7TSB3, Q9CW96, Q9D8U0
    Related
    ENSMUSP00000010192.6, ENSMUST00000010192.11
    Conserved Domains (2) summary
    pfam04836
    Location:385 → 438
    IFRD_C; Interferon-related protein conserved region
    pfam05004
    Location:32 → 339
    IFRD; Interferon-related developmental regulator (IFRD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107464917..107470237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8U0.1 GenPept UniProtKB/Swiss-Prot:Q9D8U0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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