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Idh3g isocitrate dehydrogenase 3 (NAD+), gamma [ Mus musculus (house mouse) ]

Gene ID: 15929, updated on 11-Apr-2024

Summary

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Official Symbol
Idh3gprovided by MGI
Official Full Name
isocitrate dehydrogenase 3 (NAD+), gammaprovided by MGI
Primary source
MGI:MGI:1099463
See related
Ensembl:ENSMUSG00000002010 AllianceGenome:MGI:1099463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable isocitrate dehydrogenase (NAD+) activity and magnesium ion binding activity. Predicted to be involved in several processes, including NADH metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 350.1), kidney adult (RPKM 236.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Idh3g in Genome Data Viewer
Location:
X A7.3; X 37.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72822569..72830471, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73778963..73786897, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene plexin B3 Neighboring gene serine/arginine-rich protein specific kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E11049 Neighboring gene signal sequence receptor, delta Neighboring gene STARR-seq mESC enhancer starr_47355 Neighboring gene PDZ domain containing 4 Neighboring gene predicted gene, 23615

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase. Ma T, et al. Sci Rep, 2017 Jan 31. PMID 28139779, Free PMC Article
  2. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, et al. Genomics, 1997 Aug 15. PMID 9286695
  3. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
  4. A major X-linked locus affects kidney function in mice. Leduc MS, et al. Mol Genet Genomics, 2012 Dec. PMID 23011808, Free PMC Article
  5. At Term, XmO and XpO Mouse Placentas Show Differences in Glucose Metabolism in the Trophectoderm-Derived Outer Zone. He N, et al. Front Cell Dev Biol, 2017. PMID 28680878, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
    Title: BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables isocitrate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isocitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
Names
NAD(+)-specific ICDH subunit gamma
isocitric dehydrogenase subunit gamma
NP_001343285.1
NP_001398440.1
NP_001398442.1
NP_001398445.1
NP_001398446.1
NP_001398447.1
NP_001398448.1
NP_032349.1
XP_017173881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356356.2 → NP_001343285.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672094
    UniProtKB/TrEMBL
    Q3TKM5, Q684I8
    Conserved Domains (1) summary
    TIGR00175
    Location:48 → 379
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

  2. NM_001411511.1 → NP_001398440.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672094

  3. NM_001411513.1 → NP_001398442.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672094

  4. NM_001411516.1 → NP_001398445.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672094

  5. NM_001411517.1 → NP_001398446.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672094

  6. NM_001411518.1 → NP_001398447.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672094

  7. NM_001411519.1 → NP_001398448.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL672094

  8. NM_008323.2 → NP_032349.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_032349.1

    Status: VALIDATED

    Source sequence(s)
    AL672094
    Consensus CDS
    CCDS30212.1
    UniProtKB/Swiss-Prot
    P70404
    UniProtKB/TrEMBL
    Q3TGZ3, Q684I8
    Related
    ENSMUSP00000056502.9, ENSMUST00000052761.9
    Conserved Domains (1) summary
    TIGR00175
    Location:52 → 383
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

RNA

  1. NR_177282.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672094

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72822569..72830471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318392.2 → XP_017173881.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q684I8
    Conserved Domains (1) summary
    TIGR00175
    Location:1 → 325
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70404.1 GenPept UniProtKB/Swiss-Prot:P70404

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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