U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BRD10 bromodomain containing 10 [ Homo sapiens (human) ]

Gene ID: 158358, updated on 20-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
BRD10provided by HGNC
Official Full Name
bromodomain containing 10provided by HGNC
Primary source
HGNC:HGNC:23378
See related
Ensembl:ENSG00000183354 AllianceGenome:HGNC:23378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA2026
Expression
Ubiquitous expression in testis (RPKM 4.2), thyroid (RPKM 2.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9p24.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5878834..6008482, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5881968..6013620, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5919022..6008482, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene uncharacterized LOC124902115 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:5762408-5763607 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19756 Neighboring gene Sharpr-MPRA regulatory region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19757 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:5879621-5880122 Neighboring gene small nucleolar RNA U13 Neighboring gene adenylate kinase 4 pseudogene 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:5909826-5911025 Neighboring gene melan-A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19759 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6007511-6008012 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6008013-6008512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19762 Neighboring gene microRNA 4665 Neighboring gene RAN binding protein 6 Neighboring gene uncharacterized LOC124902116

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Uhler JP, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24211586
  2. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  3. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  4. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  5. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, et al. Mol Cell, 2019 Feb 21. PMID 30639242, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized bromodomain-containing protein 10; uncharacterized protein KIAA2026

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017969.3 → NP_001017969.2  uncharacterized bromodomain-containing protein 10

    See identical proteins and their annotated locations for NP_001017969.2

    Status: VALIDATED

    Source sequence(s)
    AL162384, AL365360, BC108654, DY655479
    UniProtKB/Swiss-Prot
    A8MTP2, B9EGW7, Q4VXA2, Q5HYC2, Q8IVE5
    Related
    ENSP00000382815.3, ENST00000399933.8
    Conserved Domains (3) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    pfam05672
    Location:253 → 292
    MAP7; MAP7 (E-MAP-115) family
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    5878834..6008482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517760.4 → XP_011516062.1  uncharacterized protein KIAA2026 isoform X3

    See identical proteins and their annotated locations for XP_011516062.1

    Conserved Domains (4) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    PHA03255
    Location:1668 → 1825
    PHA03255; BDLF3; Provisional
    pfam05109
    Location:1180 → 1760
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  2. XM_011517759.4 → XP_011516061.1  uncharacterized protein KIAA2026 isoform X3

    See identical proteins and their annotated locations for XP_011516061.1

    Conserved Domains (4) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    PHA03255
    Location:1668 → 1825
    PHA03255; BDLF3; Provisional
    pfam05109
    Location:1180 → 1760
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  3. XM_047422861.1 → XP_047278817.1  uncharacterized protein KIAA2026 isoform X6

  4. XM_017014331.3 → XP_016869820.1  uncharacterized protein KIAA2026 isoform X2

  5. XM_005251385.4 → XP_005251442.1  uncharacterized protein KIAA2026 isoform X1

    UniProtKB/Swiss-Prot
    Q5HYC2
    Related
    ENSP00000370870.2, ENST00000381461.6
    Conserved Domains (3) summary
    cd04369
    Location:137 → 193
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    pfam05672
    Location:253 → 292
    MAP7; MAP7 (E-MAP-115) family
    pfam06936
    Location:225 → 287
    Selenoprotein_S; Selenoprotein S (SelS)

  6. XM_047422860.1 → XP_047278816.1  uncharacterized protein KIAA2026 isoform X5

  7. XM_024447429.2 → XP_024303197.1  uncharacterized protein KIAA2026 isoform X4

  8. XM_011517761.3 → XP_011516063.1  uncharacterized protein KIAA2026 isoform X5

    See identical proteins and their annotated locations for XP_011516063.1

    UniProtKB/Swiss-Prot
    Q5HYC2

  9. XM_047422862.1 → XP_047278818.1  uncharacterized protein KIAA2026 isoform X7

RNA

  1. XR_007061251.1 RNA Sequence

  2. XR_007061249.1 RNA Sequence

  3. XR_007061250.1 RNA Sequence

  4. XR_007061252.1 RNA Sequence

  5. XR_001746198.3 RNA Sequence

  6. XR_001746203.3 RNA Sequence

  7. XR_001746207.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    5881968..6013620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362141.1 → XP_054218116.1  uncharacterized protein KIAA2026 isoform X3

  2. XM_054362145.1 → XP_054218120.1  uncharacterized protein KIAA2026 isoform X6

  3. XM_054362140.1 → XP_054218115.1  uncharacterized protein KIAA2026 isoform X1

  4. XM_054362143.1 → XP_054218118.1  uncharacterized protein KIAA2026 isoform X5

  5. XM_054362142.1 → XP_054218117.1  uncharacterized protein KIAA2026 isoform X4

  6. XM_054362144.1 → XP_054218119.1  uncharacterized protein KIAA2026 isoform X5

  7. XM_054362146.1 → XP_054218121.1  uncharacterized protein KIAA2026 isoform X7

RNA

  1. XR_008487947.1 RNA Sequence

  2. XR_008487946.1 RNA Sequence

  3. XR_008487948.1 RNA Sequence

  4. XR_008487949.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYC2.2 GenPept UniProtKB/Swiss-Prot:Q5HYC2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous