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Mfsd14a major facilitator superfamily domain containing 14A [ Mus musculus (house mouse) ]

Gene ID: 15247, updated on 21-Apr-2024

Summary

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Official Symbol
Mfsd14aprovided by MGI
Official Full Name
major facilitator superfamily domain containing 14Aprovided by MGI
Primary source
MGI:MGI:1201609
See related
Ensembl:ENSMUSG00000089911 AllianceGenome:MGI:1201609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hiat1
Summary
Predicted to enable transmembrane transporter activity. Acts upstream of or within acrosome assembly; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 21.5), placenta adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G1; 3 50.42 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116424813..116456264, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116631164..116662688, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene splicing factor, arginine/serine-rich pseudogene Neighboring gene leucine rich repeat containing 39 Neighboring gene STARR-seq mESC enhancer starr_08780 Neighboring gene tRNA methyltransferase 13 Neighboring gene STARR-positive B cell enhancer ABC_E1630 Neighboring gene SAS-6 centriolar assembly protein Neighboring gene STARR-seq mESC enhancer starr_08781 Neighboring gene STARR-seq mESC enhancer starr_08784 Neighboring gene STARR-seq mESC enhancer starr_08785 Neighboring gene STARR-positive B cell enhancer ABC_E3464 Neighboring gene STARR-seq mESC enhancer starr_08789 Neighboring gene STARR-seq mESC enhancer starr_08790 Neighboring gene microRNA 3473h Neighboring gene solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 Neighboring gene predicted gene, 40126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice. Doran J, et al. Reproduction, 2016 Jul. PMID 27107036
  2. Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. Matsuo N, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299464
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Mfsd14a expression is associated with globozoospermia and male infertility.
    Title: Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144858

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid nucleus differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hippocampus abundant transcript 1 protein
Names
hippocampus abundant gene transcript 1
tetracycline transporter-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410014.1 → NP_001396943.1  hippocampus abundant transcript 1 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131038

  2. NM_001410015.1 → NP_001396944.1  hippocampus abundant transcript 1 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131038

  3. NM_001410016.1 → NP_001396945.1  hippocampus abundant transcript 1 protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131038

  4. NM_001410017.1 → NP_001396946.1  hippocampus abundant transcript 1 protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131038

  5. NM_001410018.1 → NP_001396947.1  hippocampus abundant transcript 1 protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131038

  6. NM_001410019.1 → NP_001396948.1  hippocampus abundant transcript 1 protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC131038

  7. NM_001410020.1 → NP_001396949.1  hippocampus abundant transcript 1 protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC131038

  8. NM_001410021.1 → NP_001396950.1  hippocampus abundant transcript 1 protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC131038

  9. NM_001410022.1 → NP_001396951.1  hippocampus abundant transcript 1 protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC131038

  10. NM_001410023.1 → NP_001396952.1  hippocampus abundant transcript 1 protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC131038

  11. NM_001410024.1 → NP_001396953.1  hippocampus abundant transcript 1 protein isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC131038

  12. NM_001410025.1 → NP_001396954.1  hippocampus abundant transcript 1 protein isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC131038

  13. NM_001410026.1 → NP_001396955.1  hippocampus abundant transcript 1 protein isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC131038

  14. NM_001410027.1 → NP_001396956.1  hippocampus abundant transcript 1 protein isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC131038

  15. NM_008246.3 → NP_032272.2  hippocampus abundant transcript 1 protein isoform 1

    See identical proteins and their annotated locations for NP_032272.2

    Status: VALIDATED

    Source sequence(s)
    AC131038
    Consensus CDS
    CCDS17790.1
    UniProtKB/Swiss-Prot
    P70187, Q3TY74, Q9DBS0
    Related
    ENSMUSP00000029570.6, ENSMUST00000029570.9
    Conserved Domains (1) summary
    cd17387
    Location:37 → 449
    MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    116424813..116456264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240023.3 → XP_011238325.1  hippocampus abundant transcript 1 protein isoform X2

    See identical proteins and their annotated locations for XP_011238325.1

    Conserved Domains (1) summary
    cd17387
    Location:1 → 377
    MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70187.3 GenPept UniProtKB/Swiss-Prot:P70187

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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