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Foxg1 forkhead box G1 [ Mus musculus (house mouse) ]

Gene ID: 15228, updated on 16-Apr-2024

Summary

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Official Symbol
Foxg1provided by MGI
Official Full Name
forkhead box G1provided by MGI
Primary source
MGI:MGI:1347464
See related
Ensembl:ENSMUSG00000020950 AllianceGenome:MGI:1347464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bf1; BF-1; Hfh9; Hfhbf1; 2900064B05Rik
Summary
Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo endoderm; hemolymphoid system; and sensory organ. Used to study Rett syndrome. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 45.4), whole brain E14.5 (RPKM 34.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Foxg1 in Genome Data Viewer
Location:
12 B3; 12 21.78 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (49429666..49433650)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (49382883..49386867)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene, 34304 Neighboring gene RIKEN cDNA 3110039M20 gene Neighboring gene predicted gene, 34381

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium. Ba R, et al. Sci Adv, 2023 Feb 15. PMID 36791184, Free PMC Article
  2. FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice. Wang J, et al. Int J Mol Sci, 2022 Nov 29. PMID 36499306, Free PMC Article
  3. Behavioral and brain anatomical analysis of Foxg1 heterozygous mice. Erickson KR, et al. PLoS One, 2022. PMID 36223387, Free PMC Article
  4. Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1. Schäffner I, et al. Mol Psychiatry, 2023 Jan. PMID 35318461, Free PMC Article
  5. FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation. Wang J, et al. J Alzheimers Dis, 2022. PMID 35180113

See all (549) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional Deletion of Foxg1 Delayed Myelination during Early Postnatal Brain Development.
    Title: Conditional Deletion of Foxg1 Delayed Myelination during Early Postnatal Brain Development.
  2. FOXG1 is involved in mouse ovarian functions and embryogenesis.
    Title: FOXG1 is involved in mouse ovarian functions and embryogenesis.
  3. FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium.
    Title: FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium.
  4. Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1.
    Title: Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1.
  5. FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice.
    Title: FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice.
  6. Behavioral and brain anatomical analysis of Foxg1 heterozygous mice.
    Title: Behavioral and brain anatomical analysis of Foxg1 heterozygous mice.
  7. FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation.
    Title: FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation.
  8. Foxg1 Upregulation Enhances Neocortical Activity.
    Title: Foxg1 Upregulation Enhances Neocortical Activity.
  9. FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes.
    Title: FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes.
  10. Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle.
    Title: Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron fate determination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pyramidal neuron migration to cerebral cortex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neural precursor cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
forkhead box protein G1
Names
HNF-3/forkhead homolog, brain factor 1
forkhead-related protein FKHL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160112.1 → NP_001153584.1  forkhead box protein G1

    See identical proteins and their annotated locations for NP_001153584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the one-exon transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC162376, AK132305, AV226567, BC046958
    Consensus CDS
    CCDS25899.1
    UniProtKB/Swiss-Prot
    Q60987, Q80VP3
    UniProtKB/TrEMBL
    Q3V1Q8
    Related
    ENSMUSP00000136372.2, ENSMUST00000179669.3
    Conserved Domains (1) summary
    smart00339
    Location:173 → 261
    FH; FORKHEAD

  2. NM_008241.2 → NP_032267.1  forkhead box protein G1

    See identical proteins and their annotated locations for NP_032267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the 2-exon transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AV226567, BC046958, CA320871, U36760
    Consensus CDS
    CCDS25899.1
    UniProtKB/Swiss-Prot
    Q60987, Q80VP3
    UniProtKB/TrEMBL
    Q3V1Q8
    Related
    ENSMUSP00000021333.4, ENSMUST00000021333.5
    Conserved Domains (1) summary
    smart00339
    Location:173 → 261
    FH; FORKHEAD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    49429666..49433650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60987.1 GenPept UniProtKB/Swiss-Prot:Q60987

Gene LinkOut

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