Mr1 major histocompatibility complex, class I-related [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mr1provided by MGI
Official Full Name: major histocompatibility complex, class I-relatedprovided by MGI
Primary source: MGI:MGI:1195463
See related: Ensembl:ENSMUSG00000026471 AllianceGenome:MGI:1195463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H2ls
Summary: Predicted to enable T cell receptor binding activity and beta-2-microglobulin binding activity. Involved in T cell differentiation in thymus and defense response to Gram-negative bacterium. Predicted to be located in endoplasmic reticulum membrane; endosome membrane; and plasma membrane. Predicted to be part of MHC class I protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human MR1 (major histocompatibility complex, class I-related). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 9.5), thymus adult (RPKM 9.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 66.45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (155003620..155022560, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (155127874..155146814, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.
Title: MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.
Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis.
Title: Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis.
Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.
Title: Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.
MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis.
Title: MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis.
Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Title: Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Study of wild-type (WT) and Mr1-/- mice were treated with antibiotics and then infected with Clostridium difficile (Cd) spores. Mr1-/- mice exhibited resistance to Cd colonization. This colonization resistance was transferred from Mr1-/- to WT mice via fecal microbiota transplantation, suggesting that Mr1-dependent factors influence the microbiota, leading to Clostridium difficile infection susceptibility.
Title: Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection.
Here the authors demonstrate that major histocompatibility complex class I deficiency results in significant dendritic atrophy along with an increase in thin dendritic spines and a reduction in stubby spines in the hippocampus of aged (12 month old) mice.
Title: Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain.
MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells.
Title: Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.
differential contribution of particular amino acids to the MAIT TCR-MR1 interaction based upon the presence of bacteria
Title: MAIT cell recognition of MR1 on bacterially infected and uninfected cells.
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Title: Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (7)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-2-microglobulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antigen processing and presentation of exogenous antigen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of MHC class I protein complex	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: major histocompatibility complex class I-related gene protein

Names: MCH class I; MHC class I-related gene protein; class I histocompatibility antigen-like protein; histocompatibility-2 complex class 1-like sequence

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355062.1 → NP_001341991.1 major histocompatibility complex class I-related gene protein isoform 2

Status: VALIDATED

Source sequence(s)

AF010448, AF010451, AK041171, AK144040

Conserved Domains (2) summary

cd07698
Location:127 → 217

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:35 → 123

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_001355063.1 → NP_001341992.1 major histocompatibility complex class I-related gene protein isoform 3

Status: VALIDATED

Source sequence(s)

AC140038, AF010448, AF010451, AK041171, AK137171

Conserved Domains (2) summary

cd07698
Location:86 → 176

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:1 → 82

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_008209.5 → NP_032235.1 major histocompatibility complex class I-related gene protein isoform 1 precursor

See identical proteins and their annotated locations for NP_032235.1

Status: VALIDATED

Source sequence(s)

AF010448, AF010451, AK041171, CJ049462

Consensus CDS

CCDS15383.1

UniProtKB/Swiss-Prot

O19478, Q8HWB0

Related

ENSMUSP00000027744.9, ENSMUST00000027744.10

Conserved Domains (2) summary

cd07698
Location:198 → 288

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:21 → 194

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2