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H2-Oa histocompatibility 2, O region alpha locus [ Mus musculus (house mouse) ]

Gene ID: 15001, updated on 21-Apr-2024

Summary

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Official Symbol
H2-Oaprovided by MGI
Official Full Name
histocompatibility 2, O region alpha locusprovided by MGI
Primary source
MGI:MGI:95924
See related
Ensembl:ENSMUSG00000024334 AllianceGenome:MGI:95924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2Oa
Summary
Predicted to enable MHC class II protein complex binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and regulation of T cell differentiation. Predicted to be part of MHC class II protein complex. Is expressed in several structures, including central nervous system; cornea; genitourinary system; palatal shelf; and salivary gland. Human ortholog(s) of this gene implicated in occupational asthma. Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 116.7), thymus adult (RPKM 40.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34311353..34314286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34092379..34095234)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11636 Neighboring gene STARR-positive B cell enhancer ABC_E5596 Neighboring gene histocompatibility 2, P region beta locus Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E11637 Neighboring gene STARR-positive B cell enhancer ABC_E7522 Neighboring gene STARR-seq mESC enhancer starr_42423 Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34266262-34266415 Neighboring gene STARR-positive B cell enhancer ABC_E117 Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene histocompatibility 2, class II, locus Mb2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunodeficiency and autoimmunity in H2-O-deficient mice. Gu Y, et al. J Immunol, 2013 Jan 1. PMID 23209323
  2. Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function. Fallas JL, et al. J Immunol, 2007 Feb 1. PMID 17237397
  3. H2-O expression in primary dendritic cells. Chen X, et al. J Immunol, 2006 Mar 15. PMID 16517723
  4. H2-O inhibits presentation of bacterial superantigens, but not endogenous self antigens. Qi L, et al. J Immunol, 2001 Aug 1. PMID 11466355
  5. Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases. Welsh RA, et al. PLoS Biol, 2020 Feb. PMID 32069316, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proper development of long-lived memory CD4 T cells requires HLA-DO function.
    Title: Proper development of long-lived memory CD4 T cells requires HLA-DO function.
  2. Mouse MHC class II chaperone H2-O antigen affects the repertoire of presented self-peptides by B cells and thymic epithelium. H2-O induces differential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor frequencies. Lack of H2-O increases autoreactivity and susceptibility to autoimmune disease development.
    Title: Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.
  3. investigated H2-O, H2-M, and I-A(b)-CLIP expression patterns in B cell subsets during B cell development and activation
    Title: Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function.
  4. H2-O predominantly inhibits antigen presentation in early endosomal compartments. Thus, H2-O appears to skew peptide loading to late endosomal/lysosomal compartments. This may favor presentation of antigens taken up by the B cell receptor.
    Title: Downmodulation of antigen presentation by H2-O in B cell lines and primary B lymphocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histocompatibility 2, O region alpha locus
Names
MHC class II antigen O region alpha locus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008206.2 → NP_032232.2  histocompatibility 2, O region alpha locus precursor

    See identical proteins and their annotated locations for NP_032232.2

    Status: VALIDATED

    Source sequence(s)
    AK020594, BC138996, CO795887
    Consensus CDS
    CCDS37577.1
    UniProtKB/TrEMBL
    B2RST7, Q9QWV1
    Related
    ENSMUSP00000025192.8, ENSMUST00000025192.8
    Conserved Domains (3) summary
    cd05767
    Location:112 → 205
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:30 → 108
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    pfam16196
    Location:203 → 250
    C1-set_C; C1-set C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34311353..34314286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160330.1 → XP_036016223.1  histocompatibility 2, O region alpha locus isoform X1

    UniProtKB/TrEMBL
    B2RST7
    Conserved Domains (2) summary
    pfam00993
    Location:1 → 78
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cd21004
    Location:81 → 175
    IgC1_MHC_II_alpha_HLA_DO; HLA class II histocompatibility antigen DO alpha; member of the C1-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version

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