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H2-DMa histocompatibility 2, class II, locus DMa [ Mus musculus (house mouse) ]

Gene ID: 14998, updated on 3-Apr-2024

Summary

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Official Symbol
H2-DMaprovided by MGI
Official Full Name
histocompatibility 2, class II, locus DMaprovided by MGI
Primary source
MGI:MGI:95921
See related
Ensembl:ENSMUSG00000037649 AllianceGenome:MGI:95921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2Ma; H2-Ma
Summary
Predicted to enable MHC class II protein complex binding activity. Involved in positive regulation of germinal center formation and positive regulation of humoral immune response. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive thymic T cell selection. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMA (major histocompatibility complex, class II, DM alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 22.7), large intestine adult (RPKM 15.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34338667..34358075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34119693..34139101)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E11637 Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E7522 Neighboring gene STARR-seq mESC enhancer starr_42423 Neighboring gene bromodomain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34266262-34266415 Neighboring gene STARR-positive B cell enhancer ABC_E117 Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene histocompatibility 2, class II, locus Mb2 Neighboring gene STARR-positive B cell enhancer ABC_E7523 Neighboring gene histocompatibility 2, class II, locus Mb1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome. Tilahun AY, et al. Am J Pathol, 2011 Jun. PMID 21641398, Free PMC Article
  2. An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. Menges PR, et al. J Immunol, 2008 Feb 1. PMID 18209058, Free PMC Article
  3. Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex. Lovitch SB, et al. J Immunol, 2006 Mar 1. PMID 16493054
  4. DM peptide-editing function leads to immunodominance in CD4 T cell responses in vivo. Nanda NK, et al. J Immunol, 2005 Nov 15. PMID 16272301
  5. Expression and function of HLA-DR3 and DQ8 in transgenic mice lacking functional H2-M. Rajagopalan G, et al. Tissue Antigens, 2003 Aug. PMID 12889995

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide antigen assembly with MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of humoral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
class II histocompatibility antigen, M alpha chain
Names
H2-M alpha
MHC class II antigen DMa
histocompatibility 2, class II, locus Ma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360530.1 → NP_001347459.1  class II histocompatibility antigen, M alpha chain precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CR974422, CR974462
    Consensus CDS
    CCDS37579.1
    UniProtKB/TrEMBL
    Q31621, Q95606, Q9QWV0
    Conserved Domains (2) summary
    smart00920
    Location:41 → 123
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cl11960
    Location:127 → 218
    Ig; Immunoglobulin domain

  2. NM_001424788.1 → NP_001411717.1  class II histocompatibility antigen, M alpha chain precursor

    Status: VALIDATED

    Source sequence(s)
    CR974422, CR974462
    UniProtKB/TrEMBL
    Q31621, Q9QWV0

  3. NM_010386.4 → NP_034516.3  class II histocompatibility antigen, M alpha chain precursor

    See identical proteins and their annotated locations for NP_034516.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK146950, CR974422
    Consensus CDS
    CCDS37579.1
    UniProtKB/TrEMBL
    Q31621, Q95606, Q9QWV0
    Related
    ENSMUSP00000037088.10, ENSMUST00000042121.11
    Conserved Domains (2) summary
    smart00920
    Location:41 → 123
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cl11960
    Location:127 → 218
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34338667..34358075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249508.1 → XP_030105368.1  class II histocompatibility antigen, M alpha chain isoform X1

    UniProtKB/TrEMBL
    Q31621, Q95606, Q9QWV0
    Conserved Domains (2) summary
    smart00920
    Location:41 → 123
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cl11960
    Location:127 → 218
    Ig; Immunoglobulin domain

  2. XM_017317260.2 → XP_017172749.1  class II histocompatibility antigen, M alpha chain isoform X1

    UniProtKB/TrEMBL
    Q31621, Q95606, Q9QWV0
    Conserved Domains (2) summary
    smart00920
    Location:41 → 123
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cl11960
    Location:127 → 218
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28078.1 GenPept UniProtKB/Swiss-Prot:P28078

Gene LinkOut

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