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Pfdn6 prefoldin subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 14976, updated on 5-Mar-2024

Summary

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Official Symbol
Pfdn6provided by MGI
Official Full Name
prefoldin subunit 6provided by MGI
Primary source
MGI:MGI:95908
See related
Ensembl:ENSMUSG00000024309 AllianceGenome:MGI:95908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ke-2; H-2Ke2; H2-Ke2
Summary
Predicted to enable amyloid-beta binding activity; chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; negative regulation of amyloid fibril formation; and protein folding. Predicted to be located in nucleus. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 40.0), liver E14 (RPKM 35.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Pfdn6 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34157883..34159317, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33938909..33940343, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5592 Neighboring gene STARR-positive B cell enhancer ABC_E7521 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34066718-34066827 Neighboring gene ral guanine nucleotide dissociation stimulator-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene WD repeat domain 46 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice. St-Jacques B, et al. Mol Cell Biol, 1990 Jan. PMID 2294398, Free PMC Article
  2. Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. Abe K, et al. EMBO J, 1988 Nov. PMID 2463160, Free PMC Article
  3. Sequence, linkage to H2-K, and function of mouse tapasin in MHC class I assembly. Grandea AG 3rd, et al. Immunogenetics, 1998 Sep. PMID 9716645
  4. The molecular organization of the H-2K region of two t-haplotypes: implications for the evolution of genetic diversity. Uehara H, et al. EMBO J, 1987 Jan. PMID 3034582, Free PMC Article
  5. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prefoldin subunit 6
Names
H2-K region expressed gene 2
protein Ke2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185182.1 → NP_001172111.1  prefoldin subunit 6

    See identical proteins and their annotated locations for NP_001172111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA023721, AV446044, CR974462
    Consensus CDS
    CCDS28636.1
    UniProtKB/Swiss-Prot
    Q03958
    UniProtKB/TrEMBL
    Q792E4
    Related
    ENSMUSP00000137072.2, ENSMUST00000179418.9
    Conserved Domains (1) summary
    cd00632
    Location:9 → 113
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

  2. NM_010385.2 → NP_034515.1  prefoldin subunit 6

    See identical proteins and their annotated locations for NP_034515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK010679, AV446044, BY238879
    Consensus CDS
    CCDS28636.1
    UniProtKB/Swiss-Prot
    Q03958
    UniProtKB/TrEMBL
    Q792E4
    Related
    ENSMUSP00000025163.8, ENSMUST00000025163.14
    Conserved Domains (1) summary
    cd00632
    Location:9 → 113
    Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34157883..34159317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03958.1 GenPept UniProtKB/Swiss-Prot:Q03958

Gene LinkOut

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