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Guk1 guanylate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 14923, updated on 5-Mar-2024

Summary

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Official Symbol
Guk1provided by MGI
Official Full Name
guanylate kinase 1provided by MGI
Primary source
MGI:MGI:95871
See related
Ensembl:ENSMUSG00000020444 AllianceGenome:MGI:95871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gmk; Guk-1
Summary
Enables ATP binding activity and guanylate kinase activity. Involved in purine nucleotide metabolic process. Located in cytosol and photoreceptor inner segment. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 72.1), ovary adult (RPKM 53.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Guk1 in Genome Data Viewer
Location:
11 B1.3; 11 37.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59074696..59083068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59183855..59192207, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene IBA57 homolog, iron-sulfur cluster assembly Neighboring gene STARR-positive B cell enhancer ABC_E5231 Neighboring gene STARR-seq mESC enhancer starr_29616 Neighboring gene gap junction protein, gamma 2 Neighboring gene STARR-positive B cell enhancer ABC_E6990 Neighboring gene RIKEN cDNA 2610507I01 gene Neighboring gene STARR-positive B cell enhancer ABC_E5232 Neighboring gene mitochondrial ribosomal protein L55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural characterization of the closed conformation of mouse guanylate kinase. Sekulic N, et al. J Biol Chem, 2002 Aug 16. PMID 12036965
  2. Cloning, characterization, and modeling of mouse and human guanylate kinases. Brady WA, et al. J Biol Chem, 1996 Jul 12. PMID 8663313
  3. Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3. Wimberg H, et al. Front Mol Neurosci, 2018. PMID 29515371, Free PMC Article
  4. The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Nechiporuk T, et al. Elife, 2016 Jan 8. PMID 26745185, Free PMC Article
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within GDP metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within GMP metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in GMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dGDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dGMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleoside monophosphate phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleotide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylate kinase
Names
GMP kinase
NP_001152882.1
NP_001390762.1
NP_001390763.1
NP_001390764.1
NP_001390765.1
NP_001390766.1
NP_032219.2
XP_006532309.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159410.2 → NP_001152882.1  guanylate kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645854
    Consensus CDS
    CCDS48809.1
    UniProtKB/TrEMBL
    E9Q7K1
    Related
    ENSMUSP00000130214.3, ENSMUST00000170895.4
    Conserved Domains (1) summary
    TIGR03263
    Location:14 → 196
    guanyl_kin; guanylate kinase

  2. NM_001403833.1 → NP_001390762.1  guanylate kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645854
    UniProtKB/TrEMBL
    E9Q7K1
    Conserved Domains (1) summary
    TIGR03263
    Location:14 → 196
    guanyl_kin; guanylate kinase

  3. NM_001403834.1 → NP_001390763.1  guanylate kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645854
    UniProtKB/TrEMBL
    E9Q7K1
    Conserved Domains (1) summary
    TIGR03263
    Location:14 → 196
    guanyl_kin; guanylate kinase

  4. NM_001403835.1 → NP_001390764.1  guanylate kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645854
    UniProtKB/Swiss-Prot
    Q564F2, Q564G0, Q64520

  5. NM_001403836.1 → NP_001390765.1  guanylate kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645854
    UniProtKB/Swiss-Prot
    Q564F2, Q564G0, Q64520

  6. NM_001403837.1 → NP_001390766.1  guanylate kinase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL645854

  7. NM_008193.4 → NP_032219.2  guanylate kinase isoform 1

    See identical proteins and their annotated locations for NP_032219.2

    Status: VALIDATED

    Source sequence(s)
    AL645854
    Consensus CDS
    CCDS24762.2
    UniProtKB/TrEMBL
    Q564G0
    Related
    ENSMUSP00000127566.3, ENSMUST00000170202.9
    Conserved Domains (2) summary
    TIGR03263
    Location:26 → 208
    guanyl_kin; guanylate kinase
    pfam00625
    Location:24 → 209
    Guanylate_kin; Guanylate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59074696..59083068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532246.2 → XP_006532309.1  guanylate kinase isoform X1

    See identical proteins and their annotated locations for XP_006532309.1

    UniProtKB/Swiss-Prot
    Q564F2, Q564G0, Q64520
    Related
    ENSMUSP00000134236.3, ENSMUST00000172714.3
    Conserved Domains (1) summary
    TIGR03263
    Location:5 → 187
    guanyl_kin; guanylate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64520.2 GenPept UniProtKB/Swiss-Prot:Q64520

Gene LinkOut

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