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rex p27 [ Human T-cell leukemia virus type I ]

Gene ID: 1491937, updated on 6-Oct-2023

Summary

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Gene symbol
rex
Gene description
p27
Locus tag
HTLV1gp6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human T-cell leukemia virus type I
Lineage
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus
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Genomic context

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Sequence:
NC_001436.1 (4773..8008)

NC_001436.1Genomic Context describing neighboring genes Neighboring gene Pr gag-pro Neighboring gene Pr gag-pro-pol Neighboring gene Pr55 Neighboring gene Neighboring gene Neighboring gene protein-coding Neighboring gene p40

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001436.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain. Nakano K, et al. Viruses, 2022 Feb 9. PMID 35215946, Free PMC Article
  2. Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms. Rende F, et al. Retrovirology, 2015 Jul 2. PMID 26133546, Free PMC Article
  3. Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex. Philip S, et al. PLoS Pathog, 2014 Apr. PMID 24699669, Free PMC Article
  4. Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication. Nakano K, et al. Microbes Infect, 2013 Jun. PMID 23541980
  5. Phosphorylation regulates human T-cell leukemia virus type 1 Rex function. Kesic M, et al. Retrovirology, 2009 Nov 17. PMID 19919707, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain.
    Title: Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain.
  2. The production of monocistronic HTLV-1 mRNAs encoding Rex isoforms with comparable activity to canonical Rex, but with distinct timing, would support a prolonged duration of Rex function with gradual loss of Tax.
    Title: Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms.
  3. When Tax/Rex expression is muted and HBZ is dominant, latent infection is established with expression of regulatory (Tax/Rex/HBZ) but not structural proteins.
    Title: Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex.
  4. Authors demonstrated that the viral RNA-binding protein, Rex, approves the stability of viral RNA by inhibiting nonsense-mediated mRNA decay.
    Title: Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication.
  5. Results suggest that the interaction of Dicer with HTLV-I Rex inhibits Dicer activity and thereby reduces the efficiency of the conversion of shRNA to siRNA.
    Title: Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing.
  6. identified two specific amino acid phosphorylation events found to be critical for Rex-1 function (Ser-97 and Thr- 174).
    Title: Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.
  7. human T-cell leukemia virus Rex protein [review]
    Title: The human T-cell leukemia virus Rex protein.
  8. The nucleoli are the route of entry of Rex into the host cell nucleus.
    Title: Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
p27

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001436.1 Reference assembly

    Range
    4773..8008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057863.1 p27 [Human T-cell leukemia virus type I]

    See identical proteins and their annotated locations for NP_057863.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1S5RIN5
    Conserved Domains (1) summary
    pfam02959
    Location:22 → 243
    Tax; HTLV Tax
Nucleotide Protein
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