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Gtpbp1 GTP binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 14904, updated on 11-Apr-2024

Summary

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Official Symbol
Gtpbp1provided by MGI
Official Full Name
GTP binding protein 1provided by MGI
Primary source
MGI:MGI:109443
See related
Ensembl:ENSMUSG00000042535 AllianceGenome:MGI:109443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GP-1; Gtpbp
Summary
Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in GTP metabolic process; positive regulation of mRNA catabolic process; and translational elongation. Predicted to be located in cytosol. Predicted to be part of cytoplasmic exosome (RNase complex). Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human GTPBP1 (GTP binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 30.9), spleen adult (RPKM 20.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.85 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79574202..79605680)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79690001..79721479)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E389 Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7390 Neighboring gene predicted gene 16576

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunocytochemical analyses and targeted gene disruption of GTPBP1. Senju S, et al. Mol Cell Biol, 2000 Sep. PMID 10938096, Free PMC Article
  2. Identification of human and mouse GP-1, a putative member of a novel G-protein family. Senju S, et al. Biochem Biophys Res Commun, 1997 Feb 13. PMID 9070279
  3. Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling. Liu DC, et al. eNeuro, 2020 Mar/Apr. PMID 32161037, Free PMC Article
  4. Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family. Watanabe M, et al. Gene, 2000 Oct 3. PMID 11054535
  5. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. Terrey M, et al. Elife, 2020 Nov 13. PMID 33186095, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling.
    Title: Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-aminoacyl-tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein 1
Names
G-protein 1
GP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013818.2 → NP_038846.2  GTP-binding protein 1

    See identical proteins and their annotated locations for NP_038846.2

    Status: VALIDATED

    Source sequence(s)
    BC046228
    Consensus CDS
    CCDS27648.1
    UniProtKB/Swiss-Prot
    O08582, Q3UD96, Q3UGW6, Q545R1, Q80ZY5
    Related
    ENSMUSP00000043575.9, ENSMUST00000046463.10
    Conserved Domains (4) summary
    cd04165
    Location:162 → 386
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:48 → 574
    GTPBP1; GTPase [General function prediction only]
    cd03694
    Location:395 → 481
    GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
    cd03708
    Location:487 → 573
    GTPBP_III; Domain III of the GP-1 family of GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79574202..79605680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520450.2 → XP_006520513.1  GTP-binding protein 1 isoform X2

    Conserved Domains (2) summary
    cd04165
    Location:50 → 274
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:1 → 462
    GTPBP1; GTPase [General function prediction only]

  2. XM_036159161.1 → XP_036015054.1  GTP-binding protein 1 isoform X1

    Conserved Domains (2) summary
    cd04165
    Location:81 → 305
    GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
    COG5258
    Location:1 → 493
    GTPBP1; GTPase [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08582.2 GenPept UniProtKB/Swiss-Prot:O08582

Gene LinkOut

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