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Gpr162 G protein-coupled receptor 162 [ Mus musculus (house mouse) ]

Gene ID: 14788, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr162provided by MGI
Official Full Name
G protein-coupled receptor 162provided by MGI
Primary source
MGI:MGI:1315214
See related
Ensembl:ENSMUSG00000038390 AllianceGenome:MGI:1315214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A-2; Grca
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in gut; nervous system; and neural retina. Orthologous to human GPR162 (G protein-coupled receptor 162). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 36.3), cerebellum adult (RPKM 34.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr162 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124835407..124840900, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124858444..124864195, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta 3 Neighboring gene STARR-positive B cell enhancer ABC_E6487 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124812982-124813183 Neighboring gene predicted gene, 32404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124814119-124814302 Neighboring gene CD4 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124829493-124829732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124836126-124836313 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124850419-124850700 Neighboring gene STARR-positive B cell enhancer ABC_E4863 Neighboring gene STARR-positive B cell enhancer ABC_E1710 Neighboring gene lymphocyte-activation gene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas. Caruso V, et al. Gene, 2014 Dec 10. PMID 25275856
  2. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam DE, et al. Biochim Biophys Acta, 2005 Apr 15. PMID 15777626
  3. Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Ansari-Lari MA, et al. Genome Res, 1998 Jan. PMID 9445485
  4. A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. Shah K, et al. J Mol Cell Biol, 2020 Jan 22. PMID 31065682, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 162
Names
gene rich cluster, A
NP_001342186.1
NP_001396767.1
NP_001396768.1
NP_001396769.1
NP_001396770.1
NP_001396772.1
NP_038561.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355257.2 → NP_001342186.1  probable G-protein coupled receptor 162 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC142254
    Consensus CDS
    CCDS20534.1
    UniProtKB/Swiss-Prot
    O88835, Q3UN16
    Related
    ENSMUSP00000145267.2, ENSMUST00000204667.2
    Conserved Domains (1) summary
    cd15906
    Location:14 → 335
    7tmA_GPR162; G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001409838.1 → NP_001396767.1  probable G-protein coupled receptor 162 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC142254
    UniProtKB/Swiss-Prot
    O88835, Q3UN16

  3. NM_001409839.1 → NP_001396768.1  probable G-protein coupled receptor 162 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC142254
    UniProtKB/Swiss-Prot
    O88835, Q3UN16

  4. NM_001409840.1 → NP_001396769.1  probable G-protein coupled receptor 162 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC142254
    UniProtKB/Swiss-Prot
    O88835, Q3UN16

  5. NM_001409841.1 → NP_001396770.1  probable G-protein coupled receptor 162 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC142254

  6. NM_001409843.1 → NP_001396772.1  probable G-protein coupled receptor 162 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC142254

  7. NM_013533.5 → NP_038561.1  probable G-protein coupled receptor 162 isoform a

    See identical proteins and their annotated locations for NP_038561.1

    Status: VALIDATED

    Source sequence(s)
    AC142254
    Consensus CDS
    CCDS20534.1
    UniProtKB/Swiss-Prot
    O88835, Q3UN16
    Related
    ENSMUSP00000038536.8, ENSMUST00000046893.10
    Conserved Domains (1) summary
    cd15906
    Location:14 → 335
    7tmA_GPR162; G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124835407..124840900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UN16.2 GenPept UniProtKB/Swiss-Prot:Q3UN16

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