Gpr37 G protein-coupled receptor 37 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr37provided by MGI
Official Full Name: G protein-coupled receptor 37provided by MGI
Primary source: MGI:MGI:1313297
See related: Ensembl:ENSMUSG00000039904 AllianceGenome:MGI:1313297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pael-R
Summary: Enables PDZ domain binding activity. Involved in dendrite development; negative regulation of hydrogen peroxide-induced cell death; and positive regulation of MAPK cascade. Acts upstream of or within dopamine biosynthetic process; locomotion involved in locomotory behavior; and positive regulation of dopamine metabolic process. Located in cell surface. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human GPR37 (G protein-coupled receptor 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 23.7), cortex adult (RPKM 13.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 11.65 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (25668522..25689979, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (25668523..25689980, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Title: GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling.
Title: Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling.
Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ.
Title: Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ.
Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei.
Title: Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei.
Inflammation and Infection in Pain and the Role of GPR37.
Title: Inflammation and Infection in Pain and the Role of GPR37.
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications.
Title: Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications.
The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.
Title: The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.
GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.
Title: GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.
GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.
Title: GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.
Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
Title: Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AJ223834 (e-PCR)
- UniSTS:163383

UniSTS:495954 (e-PCR)
- UniSTS:495954

Gpr37 (e-PCR), detects polymorphism
- UniSTS:495954

Gpr37 (e-PCR), detects polymorphism
- UniSTS:143244

AI848630 (e-PCR)
- UniSTS:179348

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables prosaposin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prosaposin receptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prosaposin receptor GPR37

Names: parkin-associated endothelin B-like receptor; probable G-protein coupled receptor 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.