Gpld1 glycosylphosphatidylinositol specific phospholipase D1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpld1provided by MGI
Official Full Name: glycosylphosphatidylinositol specific phospholipase D1provided by MGI
Primary source: MGI:MGI:106604
See related: Ensembl:ENSMUSG00000021340 AllianceGenome:MGI:106604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330541J12Rik
Summary: Enables glycosylphosphatidylinositol phospholipase D activity and sodium channel regulator activity. Involved in several processes, including positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of triglyceride metabolic process. Acts upstream of or within GPI anchor release; chondrocyte differentiation; and ossification. Located in several cellular components, including extracellular matrix; extracellular space; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 33.5), liver E18 (RPKM 30.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 10.79 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (25127135..25175919)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (24937785..24991936)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice.
Title: Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice.
Mice lacking GPI-PLD exhibited the amelioration of glucose intolerance and hepatic steatosis under high-fat and high-sucrose diet. Furthermore, diacylglycerol (DAG) content was significantly decreased, and PKCepsilon activity was suppressed in the livers of GP-KO mice.
Title: Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.
Overexpressing GPI-PLD in an insulinoma cell line enhanced glucose-stimulated insulin secretion, suggesting that enhanced insulin secretion in vivo may have contributed to the improved glucose tolerance.
Title: Glycosylphosphatidylinositol-specific phospholipase D improves glucose tolerance.
His29, His125, His133 and His158 are required for GPI-PLD catalytic activity
Title: Mutating His29, His125, His133 or His158 abolishes glycosylphosphatidylinositol-specific phospholipase D catalytic activity.
Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism.
Title: Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism.
Results suggest that cell-specific Gpld1- or peptidase-dependent pathways for prostasin secretion may control prostasin functions in a tissue-specific manner.
Title: Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
GPI-PLD expression was significantly increased in highly malignant. H-ras-transfected murine bladder carcinoma cells as compared to the low malignant, non-transfected parental cells.
Title: GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2)

General gene information

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Markers

Gpld1 (e-PCR), detects polymorphism
- UniSTS:497305

AF050666 (e-PCR)
- UniSTS:163532

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosylphosphatidylinositol phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosylphosphatidylinositol phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosylphosphatidylinositol phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in GPI anchor release	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within GPI anchor release	IDA Inferred from Direct Assay more info	PubMed
involved_in GPI anchor release	IDA Inferred from Direct Assay more info	PubMed
involved_in GPI anchor release	IGI Inferred from Genetic Interaction more info	PubMed
involved_in GPI anchor release	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to iron(II) ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to triglyceride	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in complement receptor mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of high-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol-glycan-specific phospholipase D

Names: GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D

NP_032182.2

EC 3.1.4.50

XP_011242584.1

EC 3.1.4.50

XP_030103017.1

EC 3.1.4.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008156.2 → NP_032182.2 phosphatidylinositol-glycan-specific phospholipase D precursor

See identical proteins and their annotated locations for NP_032182.2

Status: VALIDATED

Source sequence(s)

AL645533, AY081194, BY236833

Consensus CDS

CCDS26384.1

UniProtKB/TrEMBL

Q8R432, Q8VCU2, Q9DBH3

Related

ENSMUSP00000021773.6, ENSMUST00000021773.13

Conserved Domains (3) summary

smart00191
Location:446 → 502

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam01839
Location:514 → 547

FG-GAP; FG-GAP repeat

pfam00882
Location:28 → 219

Zn_dep_PLPC; Zinc dependent phospholipase C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

25127135..25175919

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247157.2 → XP_030103017.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/TrEMBL

Q8R432, Q9DBH3

Conserved Domains (2) summary

smart00191
Location:321 → 377

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam01839
Location:389 → 422

FG-GAP; FG-GAP repeat
XM_011244282.4 → XP_011242584.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

Conserved Domains (2) summary

smart00191
Location:229 → 285

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam01839
Location:297 → 330

FG-GAP; FG-GAP repeat