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Gp5 glycoprotein 5 platelet [ Mus musculus (house mouse) ]

Gene ID: 14729, updated on 21-Apr-2024

Summary

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Official Symbol
Gp5provided by MGI
Official Full Name
glycoprotein 5 plateletprovided by MGI
Primary source
MGI:MGI:1096363
See related
Ensembl:ENSMUSG00000047953 AllianceGenome:MGI:1096363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPV
Summary
Enables collagen binding activity. Acts upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Predicted to be located in cell surface. Is expressed in several structures, including hepatic primordium; liver; mesenchyme derived from splanchnopleure; placenta; and yolk sac. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 14.8), liver E14.5 (RPKM 6.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B2; 16 21.26 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30126503..30129599, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30307685..30310781, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene carboxypeptidase N, polypeptide 2 Neighboring gene leucine rich repeat containing 15 Neighboring gene ATPase type 13A3 Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30389389-30389616 Neighboring gene STARR-seq mESC enhancer starr_40576 Neighboring gene STARR-seq mESC enhancer starr_40579 Neighboring gene transmembrane protein 44 Neighboring gene predicted gene, 52252

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain. Nonne C, et al. J Thromb Haemost, 2008 Jan. PMID 17988230
  2. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Kahn ML, et al. Blood, 1999 Dec 15. PMID 10590056
  3. Cloning and characterization of the gene encoding the murine glycoprotein V: the conserved thrombin-cleavable protein on platelet surface. Katsutani S, et al. Thromb Res, 1998 Oct 1. PMID 9783673
  4. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. Moog S, et al. Blood, 2001 Aug 15. PMID 11493449
  5. Increased thrombogenesis and embolus formation in mice lacking glycoprotein V. Ni H, et al. Blood, 2001 Jul 15. PMID 11435305

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage.
    Title: Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.
  2. ROLE OF GPV IN HEMOSTASIS AND THROMBOSIS IS PROBABLY OF LESSER IMPORTANCE THAN PREVIOUSLY THOUGHT
    Title: Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain.
  3. GPV is cleaved upon agonist-induced platelet activation, with ADAM17 as the major enzyme mediating this process
    Title: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.
  4. GPIbalpha and GPV are shed through an ADAM17-dependent mechanism after aspirin administration
    Title: Aspirin induces platelet receptor shedding via ADAM17 (TACE).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood coagulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blood coagulation, intrinsic pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation, intrinsic pathway NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megakaryocyte development NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of platelet activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of platelet activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
part_of glycoprotein Ib-IX-V complex ISO
Inferred from Sequence Orthology
more info
  
part_of glycoprotein Ib-IX-V complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
platelet glycoprotein V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008148.4 → NP_032174.2  platelet glycoprotein V precursor

    See identical proteins and their annotated locations for NP_032174.2

    Status: VALIDATED

    Source sequence(s)
    AK031272, BE948546, BY235812
    Consensus CDS
    CCDS28100.1
    UniProtKB/TrEMBL
    Q3TA66, Q9QZU3
    Related
    ENSMUSP00000051895.7, ENSMUST00000061190.8
    Conserved Domains (4) summary
    cd00116
    Location:126 → 402
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:100 → 123
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:124 → 182
    LRR_8; Leucine rich repeat
    cl15307
    Location:421 → 454
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    30126503..30129599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08742.1 GenPept UniProtKB/Swiss-Prot:O08742

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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