Gna13 guanine nucleotide binding protein, alpha 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gna13provided by MGI
Official Full Name: guanine nucleotide binding protein, alpha 13provided by MGI
Primary source: MGI:MGI:95768
See related: Ensembl:ENSMUSG00000020611 AllianceGenome:MGI:95768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Galpha13
Summary: Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; multicellular organism aging; and regulation of blood pressure. Acts upstream of or within several processes, including Rho protein signal transduction; branching involved in blood vessel morphogenesis; and platelet activation. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut gland; nervous system; and sensory organ. Orthologous to human GNA13 (G protein subunit alpha 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 6.4), thymus adult (RPKM 6.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 71.88 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (109253620..109292195)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (109362794..109401369)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GNA13 promotes the proliferation and migration of lung squamous cell carcinoma cells through regulating the PI3K/AKT signaling pathway.
Title: GNA13 promotes the proliferation and migration of lung squamous cell carcinoma cells through regulating the PI3K/AKT signaling pathway.
G-protein Galpha13 functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.
Title: G-protein Gα(13) functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.
Here, the authors show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction.
Title: Myogenic vasoconstriction requires G(12)/G(13) and LARG to maintain local and systemic vascular resistance.
results define Galpha13 as a switch regulator of myofiber reprogramming, implying that modulations of Galpha13 and its downstream effectors in skeletal muscle are a potential therapeutic approach to treating metabolic diseases.
Title: Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG interaction compared to the Galpha13 activation in the absence of LARG.
Title: Potentiation of receptor responses induced by prolonged binding of Gα(13) and leukemia-associated RhoGEF.
GNA13 loss is associated with GC B-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development.
Title: GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
Selective inhibition of G12/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
Title: S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.
Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA
Title: The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma
Title: Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.
Direct Galpha13 binding to ITGB3 cytoplasmic domain regulates integrin outside-in signaling and thrombus formation in platelets.
Title: A directional switch of integrin signalling and a new anti-thrombotic strategy.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gna13 (e-PCR), detects polymorphism
- UniSTS:496665

Gna13 (e-PCR), detects polymorphism
- UniSTS:256615

RH127143 (e-PCR)
- UniSTS:208763

AU024132 (e-PCR)
- UniSTS:180359

AU043124 (e-PCR)
- UniSTS:180360

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D5 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D5 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISA Inferred from Sequence Alignment more info	PubMed
part_of heterotrimeric G-protein complex	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	EXP Inferred from Experiment more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-13

Names: G-protein subunit alpha-13; g alpha-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359034.1 → NP_001345963.1 guanine nucleotide-binding protein subunit alpha-13 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate 3' terminal exon, resulting in novel 3' UTR and 3' coding region. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK011851, BE943634, BY711071, BY742974

Consensus CDS

CCDS88277.1

UniProtKB/TrEMBL

Q9D034

Related

ENSMUSP00000102313.4, ENSMUST00000106702.4

Conserved Domains (1) summary

smart00275
Location:29 → 172

G_alpha; G protein alpha subunit
NM_010303.3 → NP_034433.3 guanine nucleotide-binding protein subunit alpha-13 isoform 1

See identical proteins and their annotated locations for NP_034433.3

Status: VALIDATED

Description

Transcript Variant: This variant 1 represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK011851, AK149766, AL645791, BC032937, CJ180381

Consensus CDS

CCDS25577.1

UniProtKB/Swiss-Prot

P27601, Q6PF99

UniProtKB/TrEMBL

Q3UE40

Related

ENSMUSP00000020930.8, ENSMUST00000020930.14

Conserved Domains (2) summary

cd00066
Location:49 → 371

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:29 → 375

G_alpha; G protein alpha subunit