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Galk1 galactokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 14635, updated on 21-Apr-2024

Summary

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Official Symbol
Galk1provided by MGI
Official Full Name
galactokinase 1provided by MGI
Primary source
MGI:MGI:95730
See related
Ensembl:ENSMUSG00000020766 AllianceGenome:MGI:95730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gk; Glk; GALK; Glk1
Summary
Enables galactokinase activity. Acts upstream of or within galactitol metabolic process and glycolytic process from galactose. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cataract and galactokinase deficiency. Orthologous to human GALK1 (galactokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 109.7), liver E18 (RPKM 50.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115899183..115903545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116008357..116012719, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SAP30 binding protein Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Lemaigre FP, et al. Biochem J, 1994 Oct 1. PMID 7945228, Free PMC Article
  2. Developmental regulation of galactokinase in suckling mouse liver by the Egr-1 transcription factor. Yang F, et al. Pediatr Res, 2004 May. PMID 14973178
  3. The murine atrial myosin light chain-2 gene: a member of an evolutionarily conserved family of contractile proteins. Doevendans PA, et al. Cytogenet Cell Genet, 2000. PMID 11124527
  4. A mouse model of galactose-induced cataracts. Ai Y, et al. Hum Mol Genet, 2000 Jul 22. PMID 10915771
  5. Evidence for unequal crossing over within the mouse T/t complex. Silver LM, et al. Proc Natl Acad Sci U S A, 1980 Oct. PMID 6934533, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Egr-1 and galactokinase have roles in a developmentally regulated chain to prepare the neonate for suckling
    Title: Developmental regulation of galactokinase in suckling mouse liver by the Egr-1 transcription factor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables galactokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactose binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within galactitol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose catabolic process via UDP-galactose IC
Inferred by Curator
more info
 PubMed 
involved_in galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within galactose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within galactose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycolytic process from galactose IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within glycolytic process from galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
galactokinase
Names
galactose kinase
NP_058601.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016905.2 → NP_058601.2  galactokinase

    See identical proteins and their annotated locations for NP_058601.2

    Status: VALIDATED

    Source sequence(s)
    AK011103, AK045694, BB771442
    Consensus CDS
    CCDS25654.1
    UniProtKB/Swiss-Prot
    Q9JIA6, Q9R0N0
    UniProtKB/TrEMBL
    Q80UL3, Q9CXZ9
    Related
    ENSMUSP00000021114.5, ENSMUST00000021114.5
    Conserved Domains (4) summary
    PRK05101
    Location:12 → 390
    PRK05101; galactokinase; Provisional
    pfam00288
    Location:128 → 193
    GHMP_kinases_N; GHMP kinases N terminal domain
    pfam08544
    Location:291 → 372
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:19 → 67
    GalKase_gal_bdg; Galactokinase galactose-binding signature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115899183..115903545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0N0.2 GenPept UniProtKB/Swiss-Prot:Q9R0N0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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