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Gli1 GLI-Kruppel family member GLI1 [ Mus musculus (house mouse) ]

Gene ID: 14632, updated on 21-Apr-2024

Summary

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Official Symbol
Gli1provided by MGI
Official Full Name
GLI-Kruppel family member GLI1provided by MGI
Primary source
MGI:MGI:95727
See related
Ensembl:ENSMUSG00000025407 AllianceGenome:MGI:95727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp5; Zfp-5
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in regulation of osteoblast differentiation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway involved in cell-cell signaling; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Orthologous to human GLI1 (GLI family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 44.9), subcutaneous fat pad adult (RPKM 27.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 74.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127165751..127177448, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127329882..127341579, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10653 Neighboring gene Rho GTPase activating protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E10654 Neighboring gene STARR-positive B cell enhancer ABC_E9811 Neighboring gene inhibin beta-E Neighboring gene inhibin beta-C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gli1 Defines a Subset of Fibro-adipogenic Progenitors that Promote Skeletal Muscle Regeneration With Less Fat Accumulation. Yao L, et al. J Bone Miner Res, 2021 Jun. PMID 33529374, Free PMC Article
  2. Gli1(+) mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Cassandras M, et al. Nat Cell Biol, 2020 Nov. PMID 33046884, Free PMC Article
  3. The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis. Kugler MC, et al. Exp Lung Res, 2019 Feb-Mar. PMID 30982371, Free PMC Article
  4. GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Degirmenci B, et al. Nature, 2018 Jun. PMID 29875413
  5. Identity of Gli1(+) cells in the bone marrow. Sena IFG, et al. Exp Hematol, 2017 Oct. PMID 28690072, Free PMC Article

See all (1112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases.
    Title: GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases.
  2. FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3beta/GLI1 pathway.
    Title: FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway.
  3. The effects of Gli1 and Gli2 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.
    Title: The effects of Gli1 and Gli2 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.
  4. The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
    Title: The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
  5. The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis.
    Title: The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis.
  6. Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting ppargamma expression.
    Title: Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression.
  7. A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling.
    Title: A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling.
  8. GLI transcriptional repression is inert prior to Hedgehog pathway activation.
    Title: GLI transcriptional repression is inert prior to Hedgehog pathway activation.
  9. Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
    Title: Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
  10. Acute Alcohol Intoxication Impairs Sonic Hedgehog-Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia.
    Title: Acute Alcohol Intoxication Impairs Sonic Hedgehog-Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia.
Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar cortex morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within notochord regression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pituitary gland development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ventral midline development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of GLI-SUFU complex ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein GLI1
Names
glioma-associated oncogene homolog
zinc finger protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010296.2 → NP_034426.2  zinc finger protein GLI1

    See identical proteins and their annotated locations for NP_034426.2

    Status: VALIDATED

    Source sequence(s)
    AC114678, AF026305, CF898732, CJ062804, CV782971
    Consensus CDS
    CCDS24238.1
    UniProtKB/Swiss-Prot
    G5E857, P47806, Q9QYK1
    UniProtKB/TrEMBL
    A2RRI7
    Related
    ENSMUSP00000026474.4, ENSMUST00000026474.5
    Conserved Domains (4) summary
    COG5236
    Location:196 → 438
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:306 → 328
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:320 → 347
    zf-H2C2_2; Zinc-finger double domain
    pfam16159
    Location:240 → 268
    FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127165751..127177448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47806.4 GenPept UniProtKB/Swiss-Prot:P47806

Gene LinkOut

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