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ZSCAN29 zinc finger and SCAN domain containing 29 [ Homo sapiens (human) ]

Gene ID: 146050, updated on 5-Mar-2024

Summary

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Official Symbol
ZSCAN29provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 29provided by HGNC
Primary source
HGNC:HGNC:26673
See related
Ensembl:ENSG00000140265 AllianceGenome:HGNC:26673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF690; Zfp690
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 6.9), lymph node (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
15q15.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43358175..43371043, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41165501..41178380, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43650373..43663241, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:43589862-43590498 Neighboring gene transglutaminase 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:43622679-43623629 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43647073-43647266 Neighboring gene adenosine deaminase like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6385 Neighboring gene tubulin gamma complex component 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene Neighboring gene tumor protein p53 binding protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43734212-43734815 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43769402-43769643 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:43784380-43785088 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:43785089-43785795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43787292-43787792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9314

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany O, et al. Am J Hum Genet, 2002 Dec. PMID 12434312, Free PMC Article
  2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  3. The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Weissmann S, et al. Cancer Res, 2018 Aug 1. PMID 29844126, Free PMC Article
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nakamura K, et al. Nat Cell Biol, 2019 Mar. PMID 30804502, Free PMC Article
  5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35867, MGC129894, MGC129895

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 29
Names
KOX31-like zinc finger protein
zinc finger protein 690

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372080.1 → NP_001359009.1  zinc finger and SCAN domain-containing protein 29

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC018924
    Consensus CDS
    CCDS10095.2
    UniProtKB/Swiss-Prot
    B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40
    Related
    ENSP00000507363.1, ENST00000684362.1
    Conserved Domains (4) summary
    smart00431
    Location:14 → 124
    SCAN; leucine rich region
    COG5048
    Location:630 → 838
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:680 → 700
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13837
    Location:408 → 493
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  2. NM_152455.4 → NP_689668.3  zinc finger and SCAN domain-containing protein 29

    See identical proteins and their annotated locations for NP_689668.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC018924, AF525399, BC017179, BC043612, DB183454, DB365228
    Consensus CDS
    CCDS10095.2
    UniProtKB/Swiss-Prot
    B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40
    Related
    ENSP00000380174.2, ENST00000396976.6
    Conserved Domains (4) summary
    smart00431
    Location:14 → 124
    SCAN; leucine rich region
    COG5048
    Location:630 → 838
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:680 → 700
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13837
    Location:408 → 493
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43358175..43371043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432187.1 → XP_047288143.1  zinc finger and SCAN domain-containing protein 29 isoform X1

    UniProtKB/Swiss-Prot
    B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40

  2. XM_047432188.1 → XP_047288144.1  zinc finger and SCAN domain-containing protein 29 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    41165501..41178380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377352.1 → XP_054233327.1  zinc finger and SCAN domain-containing protein 29 isoform X1

    UniProtKB/Swiss-Prot
    B3KVB9, Q32M75, Q32M76, Q8IWY8, Q8NA40

  2. XM_054377353.1 → XP_054233328.1  zinc finger and SCAN domain-containing protein 29 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWY8.2 GenPept UniProtKB/Swiss-Prot:Q8IWY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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