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Gem GTP binding protein overexpressed in skeletal muscle [ Mus musculus (house mouse) ]

Gene ID: 14579, updated on 21-Apr-2024

Summary

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Official Symbol
Gemprovided by MGI
Official Full Name
GTP binding protein overexpressed in skeletal muscleprovided by MGI
Primary source
MGI:MGI:99844
See related
Ensembl:ENSMUSG00000028214 AllianceGenome:MGI:99844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including calcium channel regulator activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to be involved in chromosome organization; metaphase plate congression; and mitotic cell cycle. Located in nucleus. Is expressed in several structures, including clavicle; dorsal grey horn; gut; telencephalon ventricular layer; and tooth. Orthologous to human GEM (GTP binding protein overexpressed in skeletal muscle). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 36.0), lung adult (RPKM 14.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A1; 4 5.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11702379..11714993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11704447..11714993)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09604 Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene predicted gene, 35884 Neighboring gene STARR-positive B cell enhancer ABC_E2103 Neighboring gene VISTA enhancer mm1633 Neighboring gene cadherin 17 Neighboring gene STARR-seq mESC enhancer starr_09605 Neighboring gene STARR-seq mESC enhancer starr_09606 Neighboring gene predicted gene, 54235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels. Matsuo M, et al. Cell Rep, 2022 May 24. PMID 35613591
  2. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. Gunton JE, et al. PLoS One, 2012. PMID 22761801, Free PMC Article
  3. Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations. Mahalakshmi RN, et al. Traffic, 2007 Sep. PMID 17605761
  4. Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem. Sasaki T, et al. J Biol Chem, 2005 Mar 11. PMID 15615719
  5. RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain. Béguin P, et al. J Biol Chem, 2007 Apr 13. PMID 17303572

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
    Title: Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
  2. The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy.
    Title: The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy.
  3. Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes.
    Title: RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes.
  4. These results suggest that Gem plays an important role in normal beta-cell function by regulation of calcium signalling.
    Title: Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling.
  5. Results identify specific nuclear localization signals (NLS) in Kir/Gem that are both required and sufficient for nuclear transport.
    Title: Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations.
  6. Mechanism of the inhibition of calcium channel activity by Gem.
    Title: Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem.
  7. docking of the RGK protein to the nucleotide-kinase domain of the Cavbeta subunit is reminiscent of the binding of GMP to guanylate kinase
    Title: RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain.
  8. protein expression regulation; calcium channel expression
    Title: Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein GEM
Names
GTP binding protein (gene overexpressed in skeletal muscle)
GTP-binding mitogen-induced T-cell protein
RAS-like protein KIR
NP_034406.2
XP_036019576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010276.4 → NP_034406.2  GTP-binding protein GEM

    See identical proteins and their annotated locations for NP_034406.2

    Status: VALIDATED

    Source sequence(s)
    AK158393, AK168401, BY574090
    Consensus CDS
    CCDS17971.1
    UniProtKB/Swiss-Prot
    P55041, Q8JZS1
    UniProtKB/TrEMBL
    Q3TH76
    Related
    ENSMUSP00000103939.3, ENSMUST00000108304.9
    Conserved Domains (2) summary
    smart00010
    Location:75 → 241
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:75 → 295
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11702379..11714993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163683.1 → XP_036019576.1  GTP-binding protein GEM isoform X1

    Conserved Domains (1) summary
    cd04148
    Location:75 → 281
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55041.2 GenPept UniProtKB/Swiss-Prot:P55041

Gene LinkOut

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