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Gabrg3 gamma-aminobutyric acid type A receptor, subunit gamma 3 [ Mus musculus (house mouse) ]

Gene ID: 14407, updated on 11-Apr-2024

Summary

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Official Symbol
Gabrg3provided by MGI
Official Full Name
gamma-aminobutyric acid type A receptor, subunit gamma 3provided by MGI
Primary source
MGI:MGI:95624
See related
Ensembl:ENSMUSG00000055026 AllianceGenome:MGI:95624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gabrg-3; 6330406O05Rik; B230362M20Rik
Summary
Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Is active in GABA-ergic synapse. Is integral component of synaptic membrane. Is expressed in brain and lens. Orthologous to human GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.1), cortex adult (RPKM 2.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B5; 7 33.48 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (56366211..57037173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (56716463..57387215, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_18966 Neighboring gene solute carrier family 1 (neutral amino acid transporter), member 5 pseudogene Neighboring gene oculocutaneous albinism II Neighboring gene STARR-seq mESC enhancer starr_18969 Neighboring gene predicted gene, 17984 Neighboring gene carbonic anhydrase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18970 Neighboring gene STARR-seq mESC enhancer starr_18971 Neighboring gene coronin, actin binding protein 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_18972 Neighboring gene vaccinia related kinase 3 pseudogene Neighboring gene predicted gene, 39017 Neighboring gene predicted gene 9962 Neighboring gene STARR-seq mESC enhancer starr_18974 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 5 Neighboring gene STARR-seq mESC enhancer starr_18975 Neighboring gene STARR-seq mESC enhancer starr_18976 Neighboring gene microRNA 6389 Neighboring gene GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 Neighboring gene STARR-seq mESC enhancer starr_18977

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. Wilson-Shaw D, et al. FEBS Lett, 1991 Jun 24. PMID 1647983
  2. Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Sulpizio A, et al. Life Sci, 1978 Apr 24. PMID 27681
  3. Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo. Baer K, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10536013, Free PMC Article
  4. GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo. Fritschy JM, et al. Neuroscience, 1997 Dec. PMID 9330366
  5. A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nakatsu Y, et al. Nature, 1993 Jul 29. PMID 8392662

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit gamma-3
Names
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008074.3 → NP_032100.2  gamma-aminobutyric acid receptor subunit gamma-3 precursor

    See identical proteins and their annotated locations for NP_032100.2

    Status: VALIDATED

    Source sequence(s)
    AC102098, AC102129, AC116146, AK046263
    Consensus CDS
    CCDS21320.1
    UniProtKB/Swiss-Prot
    G5E8E8, P27681
    Related
    ENSMUSP00000067632.7, ENSMUST00000068911.13
    Conserved Domains (2) summary
    TIGR00860
    Location:50 → 464
    LIC; Cation transporter family protein
    cd19000
    Location:71 → 252
    LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    56366211..57037173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321978.3 → XP_017177467.1  gamma-aminobutyric acid receptor subunit gamma-3 isoform X1

    Conserved Domains (2) summary
    TIGR00860
    Location:50 → 465
    LIC; Cation transporter family protein
    cd19000
    Location:71 → 252
    LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177273.1: Suppressed sequence

    Description
    NM_177273.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27681.2 GenPept UniProtKB/Swiss-Prot:P27681

Gene LinkOut

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