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Fnta farnesyltransferase, CAAX box, alpha [ Mus musculus (house mouse) ]

Gene ID: 14272, updated on 21-Apr-2024

Summary

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Official Symbol
Fntaprovided by MGI
Official Full Name
farnesyltransferase, CAAX box, alphaprovided by MGI
Primary source
MGI:MGI:104683
See related
Ensembl:ENSMUSG00000015994 AllianceGenome:MGI:104683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FTA
Summary
Enables acetylcholine receptor regulator activity; protein prenyltransferase activity; and receptor tyrosine kinase binding activity. Acts upstream of or within neurotransmitter receptor metabolic process. Predicted to be part of CAAX-protein geranylgeranyltransferase complex; microtubule associated complex; and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; brain; hemolymphoid system gland; and reproductive system. Orthologous to human FNTA (farnesyltransferase, CAAX box, alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 19.6), bladder adult (RPKM 17.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 14.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26488716..26505638, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25998688..26015610, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene protein-O-mannose kinase Neighboring gene predicted gene, 31402 Neighboring gene STARR-seq mESC enhancer starr_20994 Neighboring gene hook microtubule tethering protein 3 Neighboring gene STARR-seq mESC enhancer starr_20995 Neighboring gene STARR-seq mESC enhancer starr_20996 Neighboring gene RIKEN cDNA 1700047A11 gene Neighboring gene calcium binding protein 39 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion. Chen J, et al. EMBO Rep, 2020 Apr 3. PMID 32052578, Free PMC Article
  2. Genetic mapping of farnesyltransferase alpha(Fnta) to mouse chromosome 8. Porter JC, et al. Mamm Genome, 1996 Aug. PMID 8678990
  3. Cloning and sequencing of the murine farnesyltransferase alpha-encoding cDNA from a cell line which expresses the human papillomavirus type-16 E6 gene. Shirasawa H, et al. Gene, 1995 Oct 27. PMID 7590362
  4. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Jeong A, et al. Acta Neuropathol Commun, 2021 Jul 27. PMID 34315531, Free PMC Article
  5. The mevalonate pathway regulates primitive streak formation via protein farnesylation. Okamoto-Uchida Y, et al. Sci Rep, 2016 Nov 24. PMID 27883036, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
    Title: Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
  2. Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.
    Title: Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to CAAX-protein geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to protein farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to protein farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein geranylgeranyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to small molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in enzyme-linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in enzyme-linked receptor protein signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in enzyme-linked receptor protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein farnesylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein farnesylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein geranylgeranylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein prenylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to inorganic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAAX-protein geranylgeranyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein farnesyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Names
CAAX farnesyltransferase subunit alpha
FTase-alpha
GGTase-I-alpha
ras proteins prenyltransferase subunit alpha
type I protein geranyl-geranyltransferase subunit alpha
NP_032059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008033.4 → NP_032059.1  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

    See identical proteins and their annotated locations for NP_032059.1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22205.1
    UniProtKB/Swiss-Prot
    Q61239, Q921F7
    UniProtKB/TrEMBL
    Q541Z2
    Related
    ENSMUSP00000016138.10, ENSMUST00000016138.11
    Conserved Domains (1) summary
    PLN02789
    Location:64 → 365
    PLN02789; farnesyltranstransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26488716..26505638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61239.1 GenPept UniProtKB/Swiss-Prot:Q61239

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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