Ccn2 cellular communication network factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccn2provided by MGI
Official Full Name: cellular communication network factor 2provided by MGI
Primary source: MGI:MGI:95537
See related: Ensembl:ENSMUSG00000019997 AllianceGenome:MGI:95537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctgf; Hcs24; Fisp12; fisp-12
Summary: Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 127.1), ovary adult (RPKM 111.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.84 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24471340..24474581)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24595442..24598683)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2.
Title: Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2.
Context-dependent effects of CCN2 on beta-cell mass expansion and indicators of cell stress in the setting of acute and chronic stress.
Title: Context-dependent effects of CCN2 on β-cell mass expansion and indicators of cell stress in the setting of acute and chronic stress.
HMOX1 silencing prevents doxorubicin-induced cardiomyocyte injury, mitochondrial dysfunction, and ferroptosis by downregulating CTGF.
Title: HMOX1 silencing prevents doxorubicin-induced cardiomyocyte injury, mitochondrial dysfunction, and ferroptosis by downregulating CTGF.
Long noncoding RNA AI662270 promotes kidney fibrosis through enhancing METTL3-mediated m[6] A modification of CTGF mRNA.
Title: Long noncoding RNA AI662270 promotes kidney fibrosis through enhancing METTL3-mediated m(6) A modification of CTGF mRNA.
Generation of Conditional KO Mice of CCN2 and Its Function in the Kidney.
Title: Generation of Conditional KO Mice of CCN2 and Its Function in the Kidney.
CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development.
Title: CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development.
The CCN2 Polymorphism rs12526196 Is a Risk Factor for Ascending Thoracic Aortic Aneurysm.
Title: The CCN2 Polymorphism rs12526196 Is a Risk Factor for Ascending Thoracic Aortic Aneurysm.
Exosomeencapsulated miR26a attenuates aldosteroneinduced tubulointerstitial fibrosis by inhibiting the CTGF/SMAD3 signaling pathway.
Title: Exosome‑encapsulated miR‑26a attenuates aldosterone‑induced tubulointerstitial fibrosis by inhibiting the CTGF/SMAD3 signaling pathway.
Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury.
Title: Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury.
Comparative proteomics reveals elevated CCN2 in NGLY1-deficient cells.
Title: Comparative proteomics reveals elevated CCN2 in NGLY1-deficient cells.

Submit: New GeneRIF Correction See all GeneRIFs (248)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit86 (e-PCR), detects polymorphism
- UniSTS:126269

D10Mit86.1 (e-PCR), detects polymorphism
- UniSTS:126270

D10Mit86.2 (e-PCR), detects polymorphism
- UniSTS:126271

M-04697 (e-PCR)
- UniSTS:186288

Ctgf (e-PCR), detects polymorphism
- UniSTS:532669

NoName (e-PCR)
- UniSTS:548541

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage condensation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within connective tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix constituent secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCN family member 2

Names: Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); cellular communication network factor 1; fibroblast inducible secreated protein; fibroblast inducible secreted protein; hypertrophic chondrocyte-specific gene product 24; hypertrophic chondrocyte-specific protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010217.2 → NP_034347.2 CCN family member 2 precursor

See identical proteins and their annotated locations for NP_034347.2

Status: VALIDATED

Source sequence(s)

BQ031485, BQ892143, BQ917383, CB317714, CJ055589, CJ159336

Consensus CDS

CCDS23751.1

UniProtKB/Swiss-Prot

G5E830, P29268, Q922U0

Related

ENSMUSP00000020171.6, ENSMUST00000020171.12

Conserved Domains (4) summary

smart00209
Location:201 → 242

TSP1; Thrombospondin type 1 repeats

smart00214
Location:102 → 161

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:40 → 81

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:252 → 344

GHB_like; Glycoprotein hormone beta chain homologues