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Bmp2k BMP2 inducible kinase [ Mus musculus (house mouse) ]

Gene ID: 140780, updated on 11-Apr-2024

Summary

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Official Symbol
Bmp2kprovided by MGI
Official Full Name
BMP2 inducible kinaseprovided by MGI
Primary source
MGI:MGI:2155456
See related
Ensembl:ENSMUSG00000034663 AllianceGenome:MGI:2155456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIKE; 4933417M22Rik
Summary
Enables phosphatase regulator activity and protein kinase activity. Acts upstream of or within regulation of bone mineralization. Located in nucleus. Is expressed in early conceptus and secondary oocyte. Orthologous to human BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.0), spleen adult (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bmp2k in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (97143588..97239809)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96997672..97091048)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33370 Neighboring gene predicted gene 8013 Neighboring gene predicted gene, 46916 Neighboring gene STARR-positive B cell enhancer ABC_E11294 Neighboring gene STARR-seq mESC enhancer starr_13683 Neighboring gene STARR-positive B cell enhancer ABC_E1303 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:97425959-97426223 Neighboring gene predicted gene 9484 Neighboring gene STARR-positive B cell enhancer ABC_E3589 Neighboring gene STARR-seq mESC enhancer starr_13685 Neighboring gene STARR-seq mESC enhancer starr_13686 Neighboring gene progestin and adipoQ receptor family member III Neighboring gene STARR-positive B cell enhancer mm9_chr5:97540551-97540852 Neighboring gene predicted gene, 33609 Neighboring gene STARR-seq mESC enhancer starr_13687 Neighboring gene predicted gene 2861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Cendrowski J, et al. Elife, 2020 Aug 14. PMID 32795391, Free PMC Article
  2. Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. Kearns AE, et al. J Biol Chem, 2001 Nov 9. PMID 11500515
  3. Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Pawlowski TL, et al. Genomics, 2009 Sep. PMID 19501643, Free PMC Article
  4. Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. Gerber SD, et al. PLoS One, 2012. PMID 22432025, Free PMC Article
  5. An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Park EJ, et al. Development, 2008 Nov. PMID 18832392, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
    Title: Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of bone mineralization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BMP-2-inducible protein kinase
NP_001406725.1
NP_001406726.1
NP_542439.1
XP_006534851.1
XP_006534852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419796.1 → NP_001406725.1  BMP-2-inducible protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121887, AC125229

  2. NM_001419797.1 → NP_001406726.1  BMP-2-inducible protein kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121887, AC125229

  3. NM_080708.2 → NP_542439.1  BMP-2-inducible protein kinase isoform 1

    See identical proteins and their annotated locations for NP_542439.1

    Status: VALIDATED

    Source sequence(s)
    AC121887, AC125229
    Consensus CDS
    CCDS39175.1
    UniProtKB/Swiss-Prot
    Q8C8L7, Q91Z96
    Related
    ENSMUSP00000037970.8, ENSMUST00000035635.10
    Conserved Domains (3) summary
    smart00220
    Location:49 → 308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:44 → 317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:873 → 1138
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    97143588..97239809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534788.5 → XP_006534851.1  BMP-2-inducible protein kinase isoform X2

    Conserved Domains (2) summary
    cd14037
    Location:44 → 317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam12144
    Location:501 → 582
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain

  2. XM_006534789.5 → XP_006534852.1  BMP-2-inducible protein kinase isoform X3

    Related
    ENSMUSP00000108598.2, ENSMUST00000112974.6
    Conserved Domains (2) summary
    cd14037
    Location:44 → 317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam12144
    Location:501 → 582
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z96.1 GenPept UniProtKB/Swiss-Prot:Q91Z96

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