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Ube4a ubiquitination factor E4A [ Mus musculus (house mouse) ]

Gene ID: 140630, updated on 5-Mar-2024

Summary

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Official Symbol
Ube4aprovided by MGI
Official Full Name
ubiquitination factor E4Aprovided by MGI
Primary source
MGI:MGI:2154580
See related
Ensembl:ENSMUSG00000059890 AllianceGenome:MGI:2154580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UFD2b; 4732444G18Rik; 9930123J21Rik
Summary
Enables ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in cytoplasm. Is expressed in ganglia; medulla oblongata basal plate; thymus primordium; ventral grey horn; and vibrissa. Orthologous to human UBE4A (ubiquitination factor E4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 8.1), whole brain E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube4a in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44834425..44877021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44923127..44965615, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26249 Neighboring gene ATP synthase membrane subunit g Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44728805-44728988 Neighboring gene predicted gene, 30934 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44773592-44773779 Neighboring gene CD3 antigen, gamma polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CD3 antigen, delta polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of FoxOs in muscle increases strength and mitochondrial function during aging. Penniman CM, et al. J Cachexia Sarcopenia Muscle, 2023 Feb. PMID 36442857, Free PMC Article
  2. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
  3. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Hatakeyama S, et al. Genes Cells, 2004 Jun. PMID 15189447
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
    Title: Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
  2. Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
    Title: Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin conjugation factor E4 A
Names
ubiquitination factor E4A, UFD2 homolog
NP_001333627.1
NP_001348004.1
NP_001348005.1
NP_663375.3
XP_006510065.1
XP_006510066.1
XP_011240696.1
XP_011240697.1
XP_011240698.1
XP_030099909.1
XP_030099910.1
XP_030099911.1
XP_030099912.1
XP_036010503.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346698.1 → NP_001333627.1  ubiquitin conjugation factor E4 A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166048
    Consensus CDS
    CCDS85670.1
    UniProtKB/TrEMBL
    G3X9Y5, Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:1009 → 1078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349 → 990
    Ufd2P_core; Ubiquitin elongating factor core

  2. NM_001361075.1 → NP_001348004.1  ubiquitin conjugation factor E4 A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166048, AK028850
    Consensus CDS
    CCDS90555.1
    UniProtKB/TrEMBL
    Q8VDS1
    Related
    ENSMUSP00000149791.2, ENSMUST00000138559.9

  3. NM_001361076.1 → NP_001348005.1  ubiquitin conjugation factor E4 A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166048
    UniProtKB/TrEMBL
    I6L960
    Conserved Domains (1) summary
    pfam10408
    Location:253 → 846
    Ufd2P_core; Ubiquitin elongating factor core

  4. NM_145400.3 → NP_663375.3  ubiquitin conjugation factor E4 A isoform 1

    See identical proteins and their annotated locations for NP_663375.3

    Status: VALIDATED

    Source sequence(s)
    AC166048, AK172893, CN705350
    Consensus CDS
    CCDS23122.2
    UniProtKB/Swiss-Prot
    E9Q735
    UniProtKB/TrEMBL
    Q6A0C5
    Related
    ENSMUSP00000113346.2, ENSMUST00000117506.9
    Conserved Domains (2) summary
    pfam10408
    Location:330 → 933
    Ufd2P_core; Ubiquitin elongating factor core
    cd16657
    Location:952 → 1021
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins

RNA

  1. NR_153962.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166048
    Related
    ENSMUST00000154287.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44834425..44877021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510002.4 → XP_006510065.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_006510065.1

    UniProtKB/TrEMBL
    G3X9Y5, Q6A0C5
    Related
    ENSMUSP00000112632.2, ENSMUST00000117549.8
    Conserved Domains (2) summary
    cd16657
    Location:1009 → 1078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349 → 990
    Ufd2P_core; Ubiquitin elongating factor core

  2. XM_030244049.1 → XP_030099909.1  ubiquitin conjugation factor E4 A isoform X2

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:990 → 1059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330 → 971
    Ufd2P_core; Ubiquitin elongating factor core

  3. XM_030244052.1 → XP_030099912.1  ubiquitin conjugation factor E4 A isoform X4

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:913 → 982
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:253 → 894
    Ufd2P_core; Ubiquitin elongating factor core

  4. XM_006510003.5 → XP_006510066.1  ubiquitin conjugation factor E4 A isoform X2

    See identical proteins and their annotated locations for XP_006510066.1

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:990 → 1059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330 → 971
    Ufd2P_core; Ubiquitin elongating factor core

  5. XM_011242395.4 → XP_011240697.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_011240697.1

    UniProtKB/TrEMBL
    G3X9Y5, Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:1009 → 1078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349 → 990
    Ufd2P_core; Ubiquitin elongating factor core

  6. XM_011242396.4 → XP_011240698.1  ubiquitin conjugation factor E4 A isoform X2

    See identical proteins and their annotated locations for XP_011240698.1

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:990 → 1059
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:330 → 971
    Ufd2P_core; Ubiquitin elongating factor core

  7. XM_011242394.4 → XP_011240696.1  ubiquitin conjugation factor E4 A isoform X1

    See identical proteins and their annotated locations for XP_011240696.1

    UniProtKB/TrEMBL
    G3X9Y5, Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:1009 → 1078
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:349 → 990
    Ufd2P_core; Ubiquitin elongating factor core

  8. XM_030244050.2 → XP_030099910.1  ubiquitin conjugation factor E4 A isoform X4

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:913 → 982
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:253 → 894
    Ufd2P_core; Ubiquitin elongating factor core

  9. XM_030244051.2 → XP_030099911.1  ubiquitin conjugation factor E4 A isoform X4

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    cd16657
    Location:913 → 982
    RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
    pfam10408
    Location:253 → 894
    Ufd2P_core; Ubiquitin elongating factor core

  10. XM_036154610.1 → XP_036010503.1  ubiquitin conjugation factor E4 A isoform X3

    UniProtKB/TrEMBL
    Q6A0C5
    Conserved Domains (2) summary
    pfam10408
    Location:349 → 990
    Ufd2P_core; Ubiquitin elongating factor core
    cl17238
    Location:1009 → 1044
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q735.1 GenPept UniProtKB/Swiss-Prot:E9Q735

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