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F13b coagulation factor XIII, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 14060, updated on 5-Mar-2024

Summary

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Official Symbol
F13bprovided by MGI
Official Full Name
coagulation factor XIII, beta subunitprovided by MGI
Primary source
MGI:MGI:88379
See related
Ensembl:ENSMUSG00000026368 AllianceGenome:MGI:88379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cf13b; Cf-13b
Summary
This gene encodes subunit B of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit A to form a heterotetrameric protein that circulates in the plasma. During the blood coagulation process, thrombin-mediated proteolytic cleavage of the subunit A results in the dissociation of the encoded protein from the heterotetramer. Male mice lacking the encoded protein exhibit mild fibrosis together with hemosiderin deposits in the heart. [provided by RefSeq, Sep 2015]
Expression
Biased expression in liver E18 (RPKM 52.8), liver adult (RPKM 17.8) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 F; 1 61.57 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (139429285..139451496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (139501547..139523758)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5812 Neighboring gene zinc finger and BTB domain containing 41 Neighboring gene STARR-seq mESC enhancer starr_02479 Neighboring gene abnormal spindle microtubule assembly Neighboring gene STARR-seq mESC enhancer starr_02480 Neighboring gene STARR-seq mESC enhancer starr_02481 Neighboring gene complement factor H-related 1 Neighboring gene complement factor H-related 3 Neighboring gene STARR-seq mESC enhancer starr_02482 Neighboring gene STARR-seq mESC enhancer starr_02483 Neighboring gene STARR-seq mESC enhancer starr_02484

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII. Souri M, et al. Thromb Haemost, 2008 Feb. PMID 18278192
  2. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency. Strilchuk AW, et al. Blood, 2020 Dec 17. PMID 32678423, Free PMC Article
  3. Transglutaminase 2 and Factor XIII catalyze distinct substrates in differentiating osteoblastic cell line: utility of highly reactive substrate peptides. Watanabe K, et al. Amino Acids, 2013 Jan. PMID 22045386
  4. Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H. Nonaka M, et al. Genomics, 1993 Mar. PMID 8468048
  5. Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation. Silva LM, et al. Blood, 2019 Jul 18. PMID 31101623, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
    Title: Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
  2. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
    Title: Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
  3. These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
    Title: The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
  4. Physiological significance of mouse TG2 and Factor XIII through identification of substrate proteins in MC3T3-E1 cells.
    Title: Transglutaminase 2 and Factor XIII catalyze distinct substrates in differentiating osteoblastic cell line: utility of highly reactive substrate peptides.
  5. Carditis and fibrosis in FXIII-deficient mice might be caused by a faulty or delayed reparative process that was initiated by abnormal haemorrhagic events within heart tissue.
    Title: Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coagulation factor XIII B chain
Names
protein-glutamine gamma-glutamyltransferase B chain
transglutaminase B chain
NP_112441.2
XP_006529195.1
XP_006529196.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031164.2 → NP_112441.2  coagulation factor XIII B chain precursor

    See identical proteins and their annotated locations for NP_112441.2

    Status: REVIEWED

    Source sequence(s)
    AI115049, AI527143, AK149397, AW213546, BB718926
    Consensus CDS
    CCDS48386.1
    UniProtKB/Swiss-Prot
    B1AY02, Q07968
    UniProtKB/TrEMBL
    Q3UER0
    Related
    ENSMUSP00000027615.6, ENSMUST00000027615.7
    Conserved Domains (3) summary
    cd00033
    Location:275 → 329
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:214 → 268
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:275 → 580
    PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    139429285..139451496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529133.3 → XP_006529196.1  coagulation factor XIII B chain isoform X2

    UniProtKB/TrEMBL
    Q3UER0
    Conserved Domains (2) summary
    cd00033
    Location:463 → 517
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:103 → 390
    PHA02927; secreted complement-binding protein; Provisional

  2. XM_006529132.5 → XP_006529195.1  coagulation factor XIII B chain isoform X1

    UniProtKB/TrEMBL
    Q3UER0
    Conserved Domains (2) summary
    cd00033
    Location:226 → 280
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:116 → 403
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07968.2 GenPept UniProtKB/Swiss-Prot:Q07968

Gene LinkOut

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