Ppp1r3a protein phosphatase 1, regulatory subunit 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r3aprovided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 3Aprovided by MGI
Primary source: MGI:MGI:2153588
See related: Ensembl:ENSMUSG00000042717 AllianceGenome:MGI:2153588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GM; RG1; RGL
Summary: Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of protein phosphatase type 1 complex. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 3.3) and mammary gland adult (RPKM 0.6) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 A1; 6 6.31 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (14713821..14755273, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (14713822..14755274, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt.
Title: Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt.
Mice lacking Ppp1r3a are protected against pressure-overload heart failure. Condition-specific cardiac regulatory gene networks identify disease-driven changes in local and global topology and pathway organization, illuminating Ppp1r3a as a novel predicted heart failure regulator.
Title: Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Mice in which human PPP1R3A C1984DeltaAG replaced mouse PP1R3A had decreased muscle glycogen levels because failure of the truncated mutant to bind glycogen & colocalize with glycogen synthase (GS) decreased GS & increased glycogen phosphorylase activity.
Title: A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
Backcrossing of G(M)-/- mice onto two different genetic backgrounds gave rise to lean, glucose-tolerant, insulin-sensitive G(M)-/- mice indicating that at least one variant gene,is required for the development of the prediabetic phenotype of obese mice.
Title: Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background.
results show that dysfunction of subunit PPP1R3A of protein phosphatase 1 leads to weight gain, increased fat deposition and insulin resistance
Title: Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance.
Disruption of the Ppp1r3a gene does not result in either fat deposition or insulin resistance, but PPP1r3a is essential for control of glycogen metabolism by exercise.
Title: Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: protein phosphatase 1 regulatory subunit 3A

Names: protein phosphatase 1 glycogen-associated regulatory subunit; protein phosphatase 1, regulatory (inhibitor) subunit 3A; protein phosphatase type-1 glycogen targeting subunit

NP_536712.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.