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RPP25L ribonuclease P/MRP subunit p25 like [ Homo sapiens (human) ]

Gene ID: 138716, updated on 5-Mar-2024

Summary

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Official Symbol
RPP25Lprovided by HGNC
Official Full Name
ribonuclease P/MRP subunit p25 likeprovided by HGNC
Primary source
HGNC:HGNC:19909
See related
Ensembl:ENSG00000164967 AllianceGenome:HGNC:19909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf23; bA296L22.5
Summary
This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 9.6), prostate (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

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See RPP25L in Genome Data Viewer
Location:
9p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34610495..34612097, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34629041..34630643, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34610492..34612094, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34521732-34522284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19848 Neighboring gene energy homeostasis associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34546795-34547294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34555021-34555613 Neighboring gene ciliary neurotrophic factor receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34568415-34568949 Neighboring gene uncharacterized LOC105376023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34570922-34571422 Neighboring gene CNTFR antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34578559-34579533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34611012-34611565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34624191-34624739 Neighboring gene dynactin subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19852 Neighboring gene AT-rich interaction domain 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad MA, et al. Nucleic Acids Res, 2006. PMID 16998185, Free PMC Article
  2. Identification of genes related to Parkinson's disease using expressed sequence tags. Kim JM, et al. DNA Res, 2006 Dec 31. PMID 17213182
  3. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article
  4. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, et al. Nat Commun, 2021 Feb 26. PMID 33637726, Free PMC Article
  5. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Seo G, et al. Cell Rep, 2020 Jul 7. PMID 32640226, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p25-like protein
Names
RNase P protein subunit-like p25
alba-like protein C9orf23
ribonuclease P/MRP 25kDa subunit-like
rpp25-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148178.3 → NP_680544.1  ribonuclease P protein subunit p25-like protein

    See identical proteins and their annotated locations for NP_680544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL528391, BC032136
    Consensus CDS
    CCDS6559.1
    UniProtKB/Swiss-Prot
    D3DRM5, Q8N5L8
    Related
    ENSP00000368242.4, ENST00000378959.9
    Conserved Domains (1) summary
    pfam01918
    Location:27 → 89
    Alba

  2. NM_148179.3 → NP_680545.1  ribonuclease P protein subunit p25-like protein

    See identical proteins and their annotated locations for NP_680545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI016726, AL528391, DT218980
    Consensus CDS
    CCDS6559.1
    UniProtKB/Swiss-Prot
    D3DRM5, Q8N5L8
    Related
    ENSP00000297613.4, ENST00000297613.4
    Conserved Domains (1) summary
    pfam01918
    Location:27 → 89
    Alba

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    34610495..34612097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    34629041..34630643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N5L8.1 GenPept UniProtKB/Swiss-Prot:Q8N5L8

Gene LinkOut

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