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Lcn5 lipocalin 5 [ Mus musculus (house mouse) ]

Gene ID: 13863, updated on 5-Mar-2024

Summary

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Official Symbol
Lcn5provided by MGI
Official Full Name
lipocalin 5provided by MGI
Primary source
MGI:MGI:1277241
See related
Ensembl:ENSMUSG00000026937 AllianceGenome:MGI:1277241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erabp; MEP10; E-RABP
Summary
This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression
Restricted expression toward genital fat pad adult (RPKM 713.9) See more
Orthologs
all
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Genomic context

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Location:
2 A3; 2 17.68 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25547944..25552242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25657932..25662230)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lipocalin 15 Neighboring gene lipocalin 8 Neighboring gene lipocalin 6 Neighboring gene lipocalin 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. Zhang YR, et al. PLoS One, 2012. PMID 22574224, Free PMC Article
  2. Epididymis-specific lipocalin promoters. Suzuki K, et al. Asian J Androl, 2007 Jul. PMID 17589789
  3. Epididymis-specific promoter-driven gene targeting: a transcription factor which regulates epididymis-specific gene expression. Suzuki K, et al. Mol Cell Endocrinol, 2006 May 16. PMID 16414179
  4. Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry. Chaurand P, et al. Proteomics, 2003 Nov. PMID 14595821
  5. Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene. Lareyre JJ, et al. Biol Reprod, 2000 Dec. PMID 11090461

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Forkhead box A2 restricts androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.
    Title: The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables retinoid binding TAS
Traceable Author Statement
more info
 PubMed 
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within retinoic acid metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
epididymal-specific lipocalin-5
Names
epididymal retinoic acid binding protein
epididymal secretory protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042630.2 → NP_001036095.1  epididymal-specific lipocalin-5 isoform b precursor

    See identical proteins and their annotated locations for NP_001036095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AK136629, AK162355
    Consensus CDS
    CCDS38078.1
    UniProtKB/Swiss-Prot
    A2AJB7
    Related
    ENSMUSP00000097888.4, ENSMUST00000100313.4
    Conserved Domains (2) summary
    pfam00061
    Location:41 → 179
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    cl21528
    Location:31 → 48
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_001276257.1 → NP_001263186.1  epididymal-specific lipocalin-5 isoform c precursor

    See identical proteins and their annotated locations for NP_001263186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) is the same length but has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK136629, AV379690
    Consensus CDS
    CCDS71003.1
    UniProtKB/Swiss-Prot
    A2AJB7
    Related
    ENSMUSP00000097887.4, ENSMUST00000100312.10
    Conserved Domains (2) summary
    pfam00061
    Location:41 → 179
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    cl21528
    Location:31 → 48
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  3. NM_007947.3 → NP_031973.2  epididymal-specific lipocalin-5 isoform a precursor

    See identical proteins and their annotated locations for NP_031973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform a.
    Source sequence(s)
    AK021014, AK136629, AV379690
    Consensus CDS
    CCDS38079.1
    UniProtKB/Swiss-Prot
    A2AJB7, O88787, Q3TS05, Q3UW42, Q9R2C6
    Related
    ENSMUSP00000028306.7, ENSMUST00000028306.13
    Conserved Domains (2) summary
    pfam00061
    Location:41 → 179
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    cl21528
    Location:31 → 48
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25547944..25552242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497666.4 → XP_006497729.1  epididymal-specific lipocalin-5 isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:31 → 189
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_006497665.1 → XP_006497728.1  epididymal-specific lipocalin-5 isoform X1

    Conserved Domains (1) summary
    cl10502
    Location:31 → 182
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_006497669.1 → XP_006497732.1  epididymal-specific lipocalin-5 isoform X5

    Conserved Domains (1) summary
    cl10502
    Location:31 → 147
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  4. XM_006497668.2 → XP_006497731.1  epididymal-specific lipocalin-5 isoform X4

    See identical proteins and their annotated locations for XP_006497731.1

    Conserved Domains (1) summary
    cl10502
    Location:31 → 189
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  5. XM_006497667.3 → XP_006497730.1  epididymal-specific lipocalin-5 isoform X3

    See identical proteins and their annotated locations for XP_006497730.1

    Conserved Domains (1) summary
    cl10502
    Location:31 → 189
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJB7.1 GenPept UniProtKB/Swiss-Prot:A2AJB7

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