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Epha6 Eph receptor A6 [ Mus musculus (house mouse) ]

Gene ID: 13840, updated on 21-Apr-2024

Summary

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Official Symbol
Epha6provided by MGI
Official Full Name
Eph receptor A6provided by MGI
Primary source
MGI:MGI:108034
See related
Ensembl:ENSMUSG00000055540 AllianceGenome:MGI:108034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ehk2; EHK-2; Hek12; m-ehk2
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; endometrium; male reproductive gland or organ; and sensory organ. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 1.8), cortex adult (RPKM 1.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C1.3; 16 34.83 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (59473424..60431196, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (59641433..60610911, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41109 Neighboring gene STARR-seq mESC enhancer starr_41110 Neighboring gene RIKEN cDNA 4930547E14 gene Neighboring gene STARR-positive B cell enhancer ABC_E11790 Neighboring gene beta-gamma crystallin domain containing 3 Neighboring gene ribosomal oxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_41112 Neighboring gene ADP-ribosylation factor-like 6 Neighboring gene STARR-seq mESC enhancer starr_41113 Neighboring gene STARR-seq mESC enhancer starr_41115 Neighboring gene predicted gene 4660 Neighboring gene STARR-seq mESC enhancer starr_41116 Neighboring gene predicted gene 9017 Neighboring gene predicted gene, 23852 Neighboring gene STARR-seq mESC enhancer starr_41118 Neighboring gene STARR-seq mESC enhancer starr_41119 Neighboring gene protein FAM60A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Learning and memory impairment in Eph receptor A6 knockout mice. Savelieva KV, et al. Neurosci Lett, 2008 Jun 20. PMID 18450376
  2. Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea. Lee AM, et al. DNA Cell Biol, 1996 Oct. PMID 8892754
  3. Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells. Wang J, et al. J Biol Chem, 2016 Aug 26. PMID 27402841, Free PMC Article
  4. A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas. Marcelli F, et al. PLoS One, 2014. PMID 24945320, Free PMC Article
  5. Transcription factor Foxd1 is required for the specification of the temporal retina in mammals. Carreres MI, et al. J Neurosci, 2011 Apr 13. PMID 21490208, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EPHA6, a gene implicated in retinal axon guidance, is one of HMX1 targets in eye development.
    Title: A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas.
  2. These findings suggest that EphA6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits underlying aspects of learning and memory.
    Title: Learning and memory impairment in Eph receptor A6 knockout mice.
  3. HOXA13 directly regulates EphA6 and EphA7 in the developing genital tubercle.
    Title: HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 6
Names
EPH homology kinase 2
NP_031964.2
XP_006521850.1
XP_011244128.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007938.2 → NP_031964.2  ephrin type-A receptor 6

    See identical proteins and their annotated locations for NP_031964.2

    Status: VALIDATED

    Source sequence(s)
    AC118603, AC122318, AC131707, AC133940, AC134526, AC154212, AC154473, AC154632, CT009682
    Consensus CDS
    CCDS28260.2
    UniProtKB/Swiss-Prot
    B9EIV2, Q62413, Q8CCN2
    UniProtKB/TrEMBL
    G1K381
    Related
    ENSMUSP00000066734.7, ENSMUST00000068860.13
    Conserved Domains (9) summary
    cd09547
    Location:1055 → 1118
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    smart00454
    Location:1052 → 1119
    SAM; Sterile alpha motif
    cd10484
    Location:128 → 300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
    cd00063
    Location:549 → 628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:720 → 1028
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:427 → 521
    fn3; Fibronectin type III domain
    pfam07699
    Location:370 → 406
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:725 → 1024
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:648 → 720
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    59473424..60431196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521787.4 → XP_006521850.1  ephrin type-A receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    B9EIV2, Q62413, Q8CCN2
    Conserved Domains (7) summary
    cd09547
    Location:899 → 962
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    cd00063
    Location:393 → 472
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:564 → 872
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07699
    Location:214 → 250
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00041
    Location:271 → 361
    fn3; Fibronectin type III domain
    pfam14575
    Location:492 → 564
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 144
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

  2. XM_011245826.4 → XP_011244128.1  ephrin type-A receptor 6 isoform X2

    Conserved Domains (1) summary
    cd10484
    Location:128 → 300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62413.2 GenPept UniProtKB/Swiss-Prot:Q62413

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