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Emp1 epithelial membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13730, updated on 21-Apr-2024

Summary

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Official Symbol
Emp1provided by MGI
Official Full Name
epithelial membrane protein 1provided by MGI
Primary source
MGI:MGI:107941
See related
Ensembl:ENSMUSG00000030208 AllianceGenome:MGI:107941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TMP; I-8-09
Summary
Predicted to be involved in bleb assembly and cell death. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including nervous system. Orthologous to human EMP1 (epithelial membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 93.5), colon adult (RPKM 49.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 66.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135339548..135360171)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135362550..135383173)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 1, pseuodogene 1 Neighboring gene predicted gene, 52922 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:135400637-135400820 Neighboring gene predicted gene, 50630 Neighboring gene RIKEN cDNA 4930425L21 gene Neighboring gene STARR-seq mESC enhancer starr_17574

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metastatic recurrence in colorectal cancer arises from residual EMP1(+) cells. Cañellas-Socias A, et al. Nature, 2022 Nov. PMID 36352230
  2. The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity. Ben-Porath I, et al. Mol Cell Biol, 1999 May. PMID 10207076, Free PMC Article
  3. Epithelial membrane protein-1 is a biomarker of gefitinib resistance. Jain A, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087880, Free PMC Article
  4. Embryonic expression of epithelial membrane protein 1 in early neurons. Wulf P, et al. Brain Res Dev Brain Res, 1999 Sep 6. PMID 10521561
  5. CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis. Zhao B, et al. J Cardiovasc Transl Res, 2021 Feb. PMID 32162171

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bleb assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epithelial membrane protein 1
Names
EMP-1
tumor-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288627.1 → NP_001275556.1  epithelial membrane protein 1 isoform a

    See identical proteins and their annotated locations for NP_001275556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC050899
    Consensus CDS
    CCDS20647.1
    UniProtKB/Swiss-Prot
    P47801
    UniProtKB/TrEMBL
    Q3UXM2, Q4FK43
    Related
    ENSMUSP00000107538.2, ENSMUST00000111907.2
    Conserved Domains (1) summary
    pfam00822
    Location:1 → 154
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_001288628.1 → NP_001275557.1  epithelial membrane protein 1 isoform b

    See identical proteins and their annotated locations for NP_001275557.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1, which causes translation initiation at an alternate start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC122820, AK159752, BC050899
    UniProtKB/TrEMBL
    Q05BR0, Q3UXM2
    Conserved Domains (1) summary
    cl21598
    Location:1 → 126
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. NM_010128.4 → NP_034258.1  epithelial membrane protein 1 isoform a

    See identical proteins and their annotated locations for NP_034258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC122820
    Consensus CDS
    CCDS20647.1
    UniProtKB/Swiss-Prot
    P47801
    UniProtKB/TrEMBL
    Q3UXM2, Q4FK43
    Related
    ENSMUSP00000032330.10, ENSMUST00000032330.16
    Conserved Domains (1) summary
    pfam00822
    Location:1 → 154
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135339548..135360171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505502.1 → XP_006505565.1  epithelial membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505565.1

    UniProtKB/Swiss-Prot
    P47801
    UniProtKB/TrEMBL
    Q3UXM2, Q4FK43
    Related
    ENSMUSP00000145069.2, ENSMUST00000205156.3
    Conserved Domains (1) summary
    pfam00822
    Location:1 → 154
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47801.2 GenPept UniProtKB/Swiss-Prot:P47801

Gene LinkOut

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