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Elk3 ELK3, member of ETS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 13713, updated on 11-Apr-2024

Summary

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Official Symbol
Elk3provided by MGI
Official Full Name
ELK3, member of ETS oncogene familyprovided by MGI
Primary source
MGI:MGI:101762
See related
Ensembl:ENSMUSG00000008398 AllianceGenome:MGI:101762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erp; Net; Etrp; Sap-2; D430049E23Rik
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within angiogenesis; regulation of transcription, DNA-templated; and wound healing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study congenital chylothorax. Orthologous to human ELK3 (ETS transcription factor ELK3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 24.3), limb E14.5 (RPKM 16.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 48.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93083277..93147021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93247415..93311159, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40741 Neighboring gene STARR-positive B cell enhancer mm9_chr10:92631736-92632037 Neighboring gene microRNA 1931 Neighboring gene cyclin dependent kinase 17 Neighboring gene STARR-seq mESC enhancer starr_27570 Neighboring gene STARR-seq mESC enhancer starr_27572 Neighboring gene STARR-seq mESC enhancer starr_27573 Neighboring gene predicted gene, 32604 Neighboring gene STARR-positive B cell enhancer ABC_E5168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:92757691-92757800 Neighboring gene STARR-seq mESC enhancer starr_27576 Neighboring gene predicted gene, 32551 Neighboring gene STARR-positive B cell enhancer ABC_E8357 Neighboring gene STARR-seq mESC enhancer starr_27578 Neighboring gene predicted gene, 32688 Neighboring gene STARR-positive B cell enhancer ABC_E8358 Neighboring gene STARR-positive B cell enhancer ABC_E5169 Neighboring gene predicted gene, 17745

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ternary complex factor net is downregulated by hypoxia and regulates hypoxia-responsive genes. Gross C, et al. Mol Cell Biol, 2007 Jun. PMID 17403894, Free PMC Article
  2. Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum response element of the fos promoter. Giovane A, et al. Mol Cell Biol, 1997 Oct. PMID 9315625, Free PMC Article
  3. Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity. Nozaki M, et al. DNA Cell Biol, 1996 Oct. PMID 8892757
  4. ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development. Lopez M, et al. Mol Cell Biol, 1994 May. PMID 7909357, Free PMC Article
  5. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Li TZ, et al. Commun Biol, 2023 Jul 3. PMID 37400491, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5.
    Title: Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM(2.5).
  2. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
    Title: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
  3. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
    Title: Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
  4. Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.
    Title: Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.
  5. Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling.
    Title: Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition.
  6. Elk3 has distinct roles in maintaining retinal artery integrity.
    Title: Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.
  7. coexpression of KLF4 led to repression of Elk-3 promoter activity
    Title: Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
  8. ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density.
    Title: Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.
  9. Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
    Title: Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
  10. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles
    Title: Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables purine-rich negative regulatory element binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ETS domain-containing protein Elk-3
Names
ETS-domain protein ELK-3
ETS-related protein ERP
ETS-related protein NET

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282967.1 → NP_001269896.1  ETS domain-containing protein Elk-3 isoform Elk3d

    See identical proteins and their annotated locations for NP_001269896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks exon 3, but maintains the reading frame compared to variant 1. The resulting isoform (Elk3d) lacks an internal protein segment compared to isoform Elk3. Unlike isoform Elk3, this isoform is predominantly localized in the cytosol and has been shown to activate transcription (PMID:20304071).
    Source sequence(s)
    AC140379, AC161054
    Consensus CDS
    CCDS70097.1
    UniProtKB/TrEMBL
    G3UVW8
    Related
    ENSMUSP00000121754.2, ENSMUST00000151153.2
    Conserved Domains (1) summary
    smart00413
    Location:5 → 69
    ETS; erythroblast transformation specific domain

  2. NM_001322265.1 → NP_001309194.1  ETS domain-containing protein Elk-3 isoform Elk3c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at exon 3, which causes a frameshift compared to variant 1. The resulting isoform (Elk3c, also known as Net-c) is shorter, with a distinct C-terminus compared to isoform Elk3.
    Source sequence(s)
    AC140379, AC161054, AK052546
    UniProtKB/TrEMBL
    C7C6B3
    Conserved Domains (1) summary
    smart00413
    Location:5 → 89
    ETS; erythroblast transformation specific domain

  3. NM_001322268.1 → NP_001309197.1  ETS domain-containing protein Elk-3 isoform Elk3b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is alternatively spliced and lacks the mid-region of exon 3, which causes a frameshift compared to variant 1. The resulting isoform (Elk3b, also known as Net-b) is shorter, with a distinct C-terminus compared to isoform Elk3. Note, variant 2 is borderline nonsense-mediated mRNA decay (NMD) candidate; however, this variant-specific protein expression has been observed in vivo (PMID:9315625).
    Source sequence(s)
    AC140379, AC161054, AK052546
    Consensus CDS
    CCDS83749.1
    UniProtKB/TrEMBL
    C7C6B2, G3UVX2
    Related
    ENSMUSP00000122324.2, ENSMUST00000129827.8
    Conserved Domains (1) summary
    smart00413
    Location:5 → 89
    ETS; erythroblast transformation specific domain

  4. NM_013508.2 → NP_038536.2  ETS domain-containing protein Elk-3 isoform Elk3

    See identical proteins and their annotated locations for NP_038536.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (Elk3, also known as Net). This isoform is predominantly localized in the nucleus and has been shown to inhibit transcription (PMID:20304071).
    Source sequence(s)
    AC140379, AC161054, AK052546
    Consensus CDS
    CCDS24124.1
    UniProtKB/Swiss-Prot
    P41971, P97747, Q62346, Q8BWH1
    UniProtKB/TrEMBL
    Q3UZH4
    Related
    ENSMUSP00000008542.6, ENSMUST00000008542.12
    Conserved Domains (1) summary
    smart00413
    Location:5 → 89
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93083277..93147021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244871.2 → XP_030100731.1  ETS domain-containing protein Elk-3 isoform X1

    UniProtKB/Swiss-Prot
    P41971, P97747, Q62346, Q8BWH1
    UniProtKB/TrEMBL
    Q3UZH4
    Conserved Domains (1) summary
    smart00413
    Location:5 → 89
    ETS; erythroblast transformation specific domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_205536.1: Suppressed sequence

    Description
    NM_205536.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41971.3 GenPept UniProtKB/Swiss-Prot:P41971

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