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Ddx19a DEAD box helicase 19a [ Mus musculus (house mouse) ]

Gene ID: 13680, updated on 21-Apr-2024

Summary

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Official Symbol
Ddx19aprovided by MGI
Official Full Name
DEAD box helicase 19aprovided by MGI
Primary source
MGI:MGI:99526
See related
Ensembl:ENSMUSG00000015023 AllianceGenome:MGI:99526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBP5; Ddx19; Eif4a-rs1
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic stress granule and nucleus. Is expressed in several structures, including central nervous system and sensory organ. Orthologous to human DDX19A (DEAD-box helicase 19A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.6), liver E14 (RPKM 17.2) and 28 other tissues See more
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Genomic context

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Location:
8 E1; 8 57.86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111701623..111724456, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110974991..110997823, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 46052 Neighboring gene predicted gene, 39251 Neighboring gene STARR-positive B cell enhancer ABC_E1770 Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d Neighboring gene STARR-positive B cell enhancer ABC_E566 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene exosome component 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation. Pinter S, et al. Nucleic Acids Res, 2021 May 7. PMID 33823549, Free PMC Article
  2. DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation. Zhang K, et al. Cell Rep, 2019 Jan 29. PMID 30699353
  3. RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1. Rajakylä EK, et al. Nat Commun, 2015 Jan 14. PMID 25585691, Free PMC Article
  4. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Yang HS, et al. Mol Cell Biol, 2003 Jan. PMID 12482958, Free PMC Article
  5. Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gee SL, et al. Gene, 1994 Mar 25. PMID 8144024

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
    Title: A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
  2. Ddx19 is an RNA export factor required for nuclear import of the SRF coactivator MKL1
    Title: RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX19A
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
DEAD box RNA helicase DEAD5
DEAD box protein 19A
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19
Ddx19-like protein
eukaryotic translation initiation factor 4A-related sequence 1
mDEAD5
NP_001404111.1
NP_031942.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417182.1 → NP_001404111.1  ATP-dependent RNA helicase DDX19A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093451, AC132945

  2. NM_007916.2 → NP_031942.2  ATP-dependent RNA helicase DDX19A isoform 1

    See identical proteins and their annotated locations for NP_031942.2

    Status: VALIDATED

    Source sequence(s)
    AK146548, BG094410, BY302446
    Consensus CDS
    CCDS22668.1
    UniProtKB/Swiss-Prot
    Q543M2, Q61655, Q921R0
    Related
    ENSMUSP00000047898.8, ENSMUST00000040416.8
    Conserved Domains (3) summary
    PTZ00424
    Location:90 → 468
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:306 → 441
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:93 → 295
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111701623..111724456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61655.2 GenPept UniProtKB/Swiss-Prot:Q61655

Gene LinkOut

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