U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ehf ets homologous factor [ Mus musculus (house mouse) ]

Gene ID: 13661, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ehfprovided by MGI
Official Full Name
ets homologous factorprovided by MGI
Primary source
MGI:MGI:1270840
See related
Ensembl:ENSMUSG00000012350 AllianceGenome:MGI:1270840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030625L19Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; female reproductive system; nasal epithelium; and urinary system. Orthologous to human EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 16.7), bladder adult (RPKM 11.7) and 10 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 E2; 2 54.43 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103093776..103133620, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103263431..103303275, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:102913613-102913914 Neighboring gene STARR-seq mESC enhancer starr_05263 Neighboring gene APAF1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_05264 Neighboring gene STARR-seq mESC enhancer starr_05265 Neighboring gene predicted gene 13869 Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene STARR-seq mESC enhancer starr_05269 Neighboring gene cDNA sequence BC016548

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Ets transcription factor EHF as a regulator of cornea epithelial cell identity. Stephens DN, et al. J Biol Chem, 2013 Nov 29. PMID 24142692, Free PMC Article
  2. Molecular cloning and expression of Ehf, a new member of the ets transcription factor/oncoprotein gene family. Bochert MA, et al. Biochem Biophys Res Commun, 1998 May 8. PMID 9600089
  3. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland. Song EAC, et al. J Dent Res, 2023 Mar. PMID 36348499, Free PMC Article
  4. Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression. Luk IY, et al. Cell Death Differ, 2022 Nov. PMID 35606410, Free PMC Article
  5. BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Kumar R, et al. Clin Cancer Res, 2003 Aug 15. PMID 12960123

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
    Title: Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.
  2. Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
    Title: Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
  3. These data provide insights into the mechanisms underlying epithelial development and aging, identifying EHF as a regulator of cornea epithelial identity
    Title: The Ets transcription factor EHF as a regulator of cornea epithelial cell identity.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (6)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ETS homologous factor
Names
ETS domain-containing transcription factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007914.3 → NP_031940.1  ETS homologous factor

    See identical proteins and their annotated locations for NP_031940.1

    Status: VALIDATED

    Source sequence(s)
    AF035527, AK028651, BE134913, BX901906
    Consensus CDS
    CCDS16475.1
    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Related
    ENSMUSP00000087961.4, ENSMUST00000090475.10
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103093776..103133620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498703.1 → XP_006498766.1  ETS homologous factor isoform X3

    See identical proteins and their annotated locations for XP_006498766.1

    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    smart00413
    Location:205 → 292
    ETS; erythroblast transformation specific domain
    cl15755
    Location:39 → 116
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_006498699.1 → XP_006498762.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498762.1

    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  3. XM_006498697.3 → XP_006498760.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498760.1

    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Related
    ENSMUSP00000106805.2, ENSMUST00000111174.8
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  4. XM_006498698.4 → XP_006498761.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498761.1

    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  5. XM_006498695.3 → XP_006498758.1  ETS homologous factor isoform X1

    See identical proteins and their annotated locations for XP_006498758.1

    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    cd08539
    Location:50 → 127
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:217 → 304
    ETS; erythroblast transformation specific domain

  6. XM_006498702.4 → XP_006498765.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498765.1

    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  7. XM_006498701.4 → XP_006498764.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498764.1

    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  8. XM_006498700.4 → XP_006498763.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498763.1

    UniProtKB/Swiss-Prot
    O70273, Q922E8, Q922T6, Q99K12
    UniProtKB/TrEMBL
    A2BIB5
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70273.1 GenPept UniProtKB/Swiss-Prot:O70273

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous