Edn1 endothelin 1 [ Mus musculus (house mouse) ]

Gene ID: 13614, updated on 26-Mar-2024

Summary

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Official Symbol: Edn1provided by MGI
Official Full Name: endothelin 1provided by MGI
Primary source: MGI:MGI:95283
See related: Ensembl:ENSMUSG00000021367 AllianceGenome:MGI:95283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ET-1; PPET1; preproET
Summary: This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]
Expression: Broad expression in lung adult (RPKM 5.9), colon adult (RPKM 3.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

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See Edn1 in Genome Data Viewer

Location:: 13 A4; 13 20.82 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (42454952..42461466)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (42301476..42307990)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1.
Title: Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1.
Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models.
Title: Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models.
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
Title: Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
Tail stump sperm defect in Ayrshire bulls: morphogenesis of the defect.
Title: Tail stump sperm defect in Ayrshire bulls: morphogenesis of the defect.
Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer.
Title: Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer.
Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury.
Title: Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury.
Endothelin-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction.
Title: Endothelin-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction.
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Title: Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Title: Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation.
Title: Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation.

Submit: New GeneRIF Correction See all GeneRIFs (197)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U35233 (e-PCR)
- UniSTS:125731

D43775 (e-PCR)
- UniSTS:180523

Edn1 (e-PCR), detects polymorphism
- UniSTS:142959

Edn1 (e-PCR), detects polymorphism
- UniSTS:142960

Edn1 (e-PCR), detects polymorphism
- UniSTS:496826

Edn1 (e-PCR), detects polymorphism
- UniSTS:265706

D13Mit138 (e-PCR), detects polymorphism
- UniSTS:126961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables endothelin A receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin A receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables endothelin A receptor binding	ISO Inferred from Sequence Orthology more info
enables endothelin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin B receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within body fluid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to human chorionic gonadotropin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to luteinizing hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to organic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to organic substance	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway involved in heart process	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial fluid transport	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular endothelium development	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerular filtration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle process involved in oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in nitric oxide transport	ISO Inferred from Sequence Orthology more info
involved_in noradrenergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal arch artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phospholipase D-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cation channel activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell size	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of urine volume	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein kinase C deactivation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein kinase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of pH	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of systemic arterial blood pressure by endothelin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by endothelin	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in renal sodium ion absorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic excitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vein smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Weibel-Palade body	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelin-1

Names: preproendothelin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.