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E2f3 E2F transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 13557, updated on 11-Apr-2024

Summary

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Official Symbol
E2f3provided by MGI
Official Full Name
E2F transcription factor 3provided by MGI
Primary source
MGI:MGI:1096340
See related
Ensembl:ENSMUSG00000016477 AllianceGenome:MGI:1096340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E2F3b; E2f3a
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human E2F3 (E2F transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.4), limb E14.5 (RPKM 7.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See E2f3 in Genome Data Viewer
Location:
13 A3.2; 13 13.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30090558..30171172, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (29906575..29986064, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53781 Neighboring gene STARR-seq mESC enhancer starr_34047 Neighboring gene STARR-seq mESC enhancer starr_34048 Neighboring gene STARR-seq mESC enhancer starr_34049 Neighboring gene STARR-seq mESC enhancer starr_34050 Neighboring gene CDK5 regulatory subunit associated protein 1-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E8521 Neighboring gene STARR-seq mESC enhancer starr_34055 Neighboring gene STARR-seq mESC enhancer starr_34056 Neighboring gene STARR-positive B cell enhancer mm9_chr13:29830009-29830310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:29838382-29838565 Neighboring gene STARR-positive B cell enhancer ABC_E7218 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:29947409-29947592 Neighboring gene predicted gene, 52084 Neighboring gene STARR-positive B cell enhancer ABC_E9871 Neighboring gene STARR-positive B cell enhancer ABC_E211 Neighboring gene STARR-seq mESC enhancer starr_34059 Neighboring gene STARR-seq mESC enhancer starr_34060 Neighboring gene predicted gene, 40860 Neighboring gene STARR-seq mESC enhancer starr_34062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:30176986-30177169 Neighboring gene STARR-seq mESC enhancer starr_34063 Neighboring gene predicted gene, 23206 Neighboring gene membrane bound O-acyltransferase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression. Liu Z, et al. Cell Death Dis, 2021 Dec 6. PMID 34873170, Free PMC Article
  2. Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice. Kim HR, et al. Int J Med Sci, 2019. PMID 31839743, Free PMC Article
  3. Fosb Induction in Nucleus Accumbens by Cocaine Is Regulated by E2F3a. Cates HM, et al. eNeuro, 2019 Mar-Apr. PMID 30963104, Free PMC Article
  4. Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing. Cates HM, et al. Biol Psychiatry, 2018 Aug 1. PMID 29397901, Free PMC Article
  5. MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo. Tang Z, et al. Int J Mol Sci, 2017 Mar 31. PMID 28362317, Free PMC Article

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.
    Title: Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.
  2. Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression.
    Title: Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression.
  3. Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3.
    Title: Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3.
  4. RB-mediated repression of E2F3 is critical for the maintenance of cell cycle exit and terminal differentiation in adult mouse Sertoli cells.
    Title: Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis.
  5. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
    Title: Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.
  6. E2F3a is a novel, upstream regulator of the addiction-mediating transcription factor DeltaFosB in NAc.
    Title: Fosb Induction in Nucleus Accumbens by Cocaine Is Regulated by E2F3a.
  7. The study showed that E2f3a, but not E2f3b, overexpression or knockdown in mouse nucleus accumbens regulates cocaine-induced locomotor and place conditioning behavior.
    Title: Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing.
  8. HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3
    Title: HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3).
  9. E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice
    Title: An Rb family-independent E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice.
  10. Findings identify E2f3 as a key transcription factor in tumor-associated macrophages (TAMs), which influences the tumor microenvironment and tumor cell metastasis.
    Title: E2f3 in tumor macrophages promotes lung metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0075

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor E2F3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289920.1 → NP_001276849.1  transcription factor E2F3 isoform E2f3b

    See identical proteins and their annotated locations for NP_001276849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as E2f3b) differs in the 5' UTR and the 5' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform E2f3b, which is shorter and has a distinct N-terminus, compared to isoform E2f3a.
    Source sequence(s)
    AK129048, AK133828, AL513025, BQ176318, BU705601
    Consensus CDS
    CCDS88434.1
    UniProtKB/TrEMBL
    Q3TMJ9, Q8R1S8
    Related
    ENSMUSP00000152368.2, ENSMUST00000222730.2
    Conserved Domains (2) summary
    cd14660
    Location:123 → 223
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:49 → 112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. NM_001359994.1 → NP_001346923.1  transcription factor E2F3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL513025
    Consensus CDS
    CCDS88435.1
    UniProtKB/TrEMBL
    A0A1Y7VML1, Q8R1S8
    Related
    ENSMUSP00000152782.2, ENSMUST00000221536.2
    Conserved Domains (2) summary
    cd14660
    Location:129 → 229
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:55 → 118
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  3. NM_010093.3 → NP_034223.1  transcription factor E2F3 isoform E2f3a

    See identical proteins and their annotated locations for NP_034223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as E2f3a) represents the longer transcript and encodes the longer isoform (E2f3a).
    Source sequence(s)
    AK133828, AV509156, BC059262
    Consensus CDS
    CCDS26413.1
    UniProtKB/Swiss-Prot
    O35261, Q5T0I6
    UniProtKB/TrEMBL
    Q3UZJ0
    Related
    ENSMUSP00000100012.4, ENSMUST00000102948.11
    Conserved Domains (2) summary
    cd14660
    Location:246 → 346
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:172 → 235
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30090558..30171172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247136.2 → XP_030102996.1  transcription factor E2F3 isoform X3

    Conserved Domains (2) summary
    cd14660
    Location:240 → 340
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:165 → 229
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. XM_011244276.4 → XP_011242578.1  transcription factor E2F3 isoform X2

    Conserved Domains (2) summary
    cd14660
    Location:250 → 350
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:175 → 239
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  3. XM_011244275.4 → XP_011242577.1  transcription factor E2F3 isoform X1

    Conserved Domains (2) summary
    cd14660
    Location:256 → 356
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:181 → 245
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  4. XM_036157843.1 → XP_036013736.1  transcription factor E2F3 isoform X4

    UniProtKB/TrEMBL
    Q8R1S8
    Conserved Domains (2) summary
    cd14660
    Location:144 → 244
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:70 → 133
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35261.2 GenPept UniProtKB/Swiss-Prot:O35261

Gene LinkOut

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