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Dpp4 dipeptidylpeptidase 4 [ Mus musculus (house mouse) ]

Gene ID: 13482, updated on 16-Apr-2024

Summary

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Official Symbol
Dpp4provided by MGI
Official Full Name
dipeptidylpeptidase 4provided by MGI
Primary source
MGI:MGI:94919
See related
Ensembl:ENSMUSG00000035000 AllianceGenome:MGI:94919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd26; THAM; Dpp-4
Summary
Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 30.2), small intestine adult (RPKM 11.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Dpp4 in Genome Data Viewer
Location:
2 C1.3; 2 35.85 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62160417..62242635, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62330073..62412315, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04636 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 Neighboring gene STARR-seq mESC enhancer starr_04637 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62123780-62124080 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62229877-62230177 Neighboring gene STARR-seq mESC enhancer starr_04638 Neighboring gene STARR-seq mESC enhancer starr_04639 Neighboring gene STARR-positive B cell enhancer ABC_E5925 Neighboring gene STARR-positive B cell enhancer ABC_E8786 Neighboring gene STARR-positive B cell enhancer ABC_E8787 Neighboring gene STARR-seq mESC enhancer starr_04641 Neighboring gene STARR-positive B cell enhancer ABC_E3379 Neighboring gene STARR-positive B cell enhancer ABC_E2037 Neighboring gene STARR-positive B cell enhancer ABC_E5926 Neighboring gene STARR-positive B cell enhancer ABC_E5927 Neighboring gene Gcg promoter region Neighboring gene predicted gene 13561 Neighboring gene glucagon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis. Koyanagi Y, et al. Physiol Rep, 2023 Mar. PMID 36949656, Free PMC Article
  2. Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression. Trzaskalski NA, et al. JCI Insight, 2023 Jan 24. PMID 36472923, Free PMC Article
  3. SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways. Verma AK, et al. JCI Insight, 2022 Dec 22. PMID 36378534, Free PMC Article
  4. CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution. Vukelic I, et al. Int J Mol Sci, 2022 May 14. PMID 35628317, Free PMC Article
  5. Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion. Patarrão RS, et al. Diabetologia, 2022 May. PMID 35190847, Free PMC Article

See all (220) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.
    Title: Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.
  2. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.
    Title: Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.
  3. Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis.
    Title: Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis.
  4. Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
    Title: Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
  5. FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
    Title: FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
  6. Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.
    Title: Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.
  7. Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization.
    Title: Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization.
  8. Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers.
    Title: Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers.
  9. CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution.
    Title: CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution.
  10. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4.
    Title: Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4.
Submit: New GeneRIF Correction See all GeneRIFs (117)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables chemorepellent activity ISO
Inferred from Sequence Orthology
more info
  
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B-1a B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within psychomotor behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 4
Names
DPP IV
T-cell activation antigen CD26
dipeptidyl peptidase IV
thymocyte-activating molecule
NP_001153015.1
NP_034204.1
XP_006498754.1
XP_006498755.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159543.1 → NP_001153015.1  dipeptidyl peptidase 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK085370, AK163085, AL928804
    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    pfam00930
    Location:102 → 472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam00326
    Location:553 → 729
    Peptidase_S9; Prolyl oligopeptidase family
    pfam18811
    Location:36 → 56
    DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region

  2. NM_010074.3 → NP_034204.1  dipeptidyl peptidase 4 isoform 1

    See identical proteins and their annotated locations for NP_034204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK085370, AK163085, AL928804
    Consensus CDS
    CCDS16065.1
    UniProtKB/Swiss-Prot
    P28843, Q3U514
    UniProtKB/TrEMBL
    Q3TR43
    Related
    ENSMUSP00000044050.8, ENSMUST00000047812.8
    Conserved Domains (3) summary
    COG1506
    Location:392 → 758
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:553 → 757
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:102 → 472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    62160417..62242635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498691.5 → XP_006498754.1  dipeptidyl peptidase 4 isoform X2

    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    pfam00930
    Location:102 → 472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam18811
    Location:37 → 56
    DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
    cl21494
    Location:553 → 678
    Abhydrolase; alpha/beta hydrolases

  2. XM_006498692.5 → XP_006498755.1  dipeptidyl peptidase 4 isoform X1

    UniProtKB/TrEMBL
    Q3TR43
    Conserved Domains (3) summary
    pfam00930
    Location:102 → 472
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam18811
    Location:37 → 56
    DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
    cl21494
    Location:553 → 679
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28843.3 GenPept UniProtKB/Swiss-Prot:P28843

Gene LinkOut

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