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Trdmt1 tRNA aspartic acid methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 13434, updated on 21-Apr-2024

Summary

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Official Symbol
Trdmt1provided by MGI
Official Full Name
tRNA aspartic acid methyltransferase 1provided by MGI
Primary source
MGI:MGI:1274787
See related
Ensembl:ENSMUSG00000026723 AllianceGenome:MGI:1274787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnmt2; Rnmt2; met-2; m.MmuIIP
Summary
Enables tRNA (cytosine-5-)-methyltransferase activity. Involved in tRNA stabilization. Acts upstream of or within tRNA methylation. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; reproductive system; thymus; and thyroid gland. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 2.1), bladder adult (RPKM 2.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 10.0 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (13509690..13549475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (13504879..13544797, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5888 Neighboring gene STARR-seq mESC enhancer starr_03701 Neighboring gene STARR-seq mESC enhancer starr_03702 Neighboring gene predicted gene 13270 Neighboring gene cubilin Neighboring gene predicted gene, 57686 Neighboring gene STARR-seq mESC enhancer starr_03707 Neighboring gene STARR-positive B cell enhancer ABC_E11702 Neighboring gene STARR-seq mESC enhancer starr_03708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:13466299-13466482 Neighboring gene predicted gene, 54102 Neighboring gene predicted gene 9875

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Zhang Y, et al. Nat Cell Biol, 2018 May. PMID 29695786, Free PMC Article
  2. Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts. Lewinska A, et al. J Cell Physiol, 2017 Dec. PMID 28177119
  3. Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth. Ghanbarian H, et al. PLoS One, 2016. PMID 27270731, Free PMC Article
  4. The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis. Tuorto F, et al. EMBO J, 2015 Sep 14. PMID 26271101, Free PMC Article
  5. Dnmt2-null sperm block maternal transmission of a paramutant phenotype†. Yu T, et al. Biol Reprod, 2021 Sep 14. PMID 33929014, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
    Title: Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
  2. Dnmt2-null sperm block maternal transmission of a paramutant phenotypedagger.
    Title: Dnmt2-null sperm block maternal transmission of a paramutant phenotype†.
  3. We also show that Q-dependent stimulation of Dnmt2 is conserved in mice. Our findings reveal a direct mechanism for the regulation of translational speed and fidelity in eukaryotes by a nutrient originating from bacteria.
    Title: Queuine links translational control in eukaryotes to a micronutrient from bacteria.
  4. Dnmt2 functions as a genetic factor that is essential in shaping the sperm RNA 'coding signature that is responsible for the intergenerational transmission of HFD-induced paternal metabolic disorders.
    Title: Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
  5. Dnmt2 may promote lifespan in the control conditions and survival during stress conditions in mouse fibroblasts.
    Title: Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts.
  6. Dnmt2 plays an unexpected role for regulation of cardiac growth by modulating activity of the P-TEFb complex.
    Title: Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth.
  7. Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro.
    Title: Aging is associated with hypermethylation of autophagy genes in macrophages.
  8. Dnmt2 plays an important role in haematopoiesis and define a novel function of C38 tRNA methylation in the discrimination of near-cognate codons, thereby ensuring accurate polypeptide synthesis.
    Title: The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.
  9. these findings uncover a novel function of Dnmt2 in RNA-mediated epigenetic heredity
    Title: RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.
  10. Dnmt2-dependent methylomes lack defined DNA methylation patterns.
    Title: Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA methylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (cytosine(38)-C(5))-methyltransferase
Names
DNA (cytosine-5)-methyltransferase-like protein 2
DNA MTase homolog MmuIIP
DNA methyltransferase 2
DNA methyltransferase homolog MmuIIP
tRNA (cytosine-5-)-methyltransferase
NP_001403924.1
NP_001403925.1
NP_001403926.1
NP_001403927.1
NP_001403928.1
NP_034197.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416995.1 → NP_001403924.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

  2. NM_001416996.1 → NP_001403925.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

  3. NM_001416997.1 → NP_001403926.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

  4. NM_001416998.1 → NP_001403927.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

  5. NM_001416999.1 → NP_001403928.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

  6. NM_010067.5 → NP_034197.3  tRNA (cytosine(38)-C(5))-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_034197.3

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538
    Consensus CDS
    CCDS15695.1
    UniProtKB/Swiss-Prot
    O35212, O55055
    UniProtKB/TrEMBL
    Q5I0V6, Q8C7F0
    Related
    ENSMUSP00000114572.2, ENSMUST00000124488.7
    Conserved Domains (1) summary
    cd00315
    Location:4 → 391
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RNA

  1. NR_184406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

  2. NR_184407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772303, AL773538

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    13509690..13549475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55055.2 GenPept UniProtKB/Swiss-Prot:O55055

Gene LinkOut

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