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Dync1i2 dynein cytoplasmic 1 intermediate chain 2 [ Mus musculus (house mouse) ]

Gene ID: 13427, updated on 21-Apr-2024

Summary

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Official Symbol
Dync1i2provided by MGI
Official Full Name
dynein cytoplasmic 1 intermediate chain 2provided by MGI
Primary source
MGI:MGI:107750
See related
Ensembl:ENSMUSG00000027012 AllianceGenome:MGI:107750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dncic2; 3110079H08Rik
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in negative regulation of neuron projection development and transport along microtubule. Part of outer dynein arm. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb bud; and nose. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 64.5), CNS E14 (RPKM 54.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C2; 2 42.38 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71041999..71093647)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71211676..71263303)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome b reductase 1 Neighboring gene STARR-seq mESC enhancer starr_04772 Neighboring gene predicted gene, 39576 Neighboring gene STARR-seq mESC enhancer starr_04777 Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71198352-71198535 Neighboring gene STARR-seq mESC enhancer starr_04786 Neighboring gene STARR-seq mESC enhancer starr_04790 Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. Kuta A, et al. PLoS One, 2010 Jul 21. PMID 20657784, Free PMC Article
  2. Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis. Pyr dit Ruys S, et al. Biochim Biophys Acta, 2009 Nov. PMID 19744529
  3. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. Crackower MA, et al. Genomics, 1999 Feb 1. PMID 10049579
  4. ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. Shah M, et al. J Cell Biol, 2013 Jul 8. PMID 23836931, Free PMC Article
  5. Animal models of lysosomal disease: an overview. Suzuki K, et al. J Inherit Metab Dis, 1998 Aug. PMID 9728334

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SQSTM1 is required for proper dynein motility and trafficking along microtubules.
    Title: Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.
  2. Study found Dync1i2 has 11 isoforms: six including exon 1a, five including exon 1b; isoforms with the same exon content other than exon 1a and 1b have similar but not identical expression patterns.
    Title: Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of outer dynein arm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoplasmic dynein 1 intermediate chain 2
Names
DH IC-2
dynein intermediate chain 2, cytosolic
dynein, cytoplasmic, intermediate chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198872.1 → NP_001185801.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001185801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1; also called 1a.D) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 6 encode the same protein.
    Source sequence(s)
    BQ174310, BY065048, GU992208
    UniProtKB/TrEMBL
    D6Q0F5, Q3UDA2
    Conserved Domains (4) summary
    COG2319
    Location:346 → 616
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:152 → 180
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:356 → 394
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:397 → 622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001198873.1 → NP_001185802.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001185802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2; also called 1a.E) uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 2 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
    Source sequence(s)
    BQ174310, BY065048, GU992209
    UniProtKB/TrEMBL
    D6Q0F6, Q3UDA2
    Conserved Domains (4) summary
    COG2319
    Location:341 → 611
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:147 → 175
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:351 → 389
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:392 → 617
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001198874.1 → NP_001185803.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

    See identical proteins and their annotated locations for NP_001185803.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3; also called 1a.B) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 3 encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK141837, BQ174310, BY065048
    Consensus CDS
    CCDS57175.1
    UniProtKB/TrEMBL
    Q3TPJ8, Q3UDA2
    Related
    ENSMUSP00000107770.2, ENSMUST00000112142.8
    Conserved Domains (3) summary
    COG2319
    Location:323 → 593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333 → 371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129 → 157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  4. NM_001198875.1 → NP_001185804.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

    See identical proteins and their annotated locations for NP_001185804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4; also called 1a.F) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 4 encodes a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    BQ174310, BY065048, GU992210
    UniProtKB/TrEMBL
    D6Q0F7, Q3UDA2
    Conserved Domains (3) summary
    COG2319
    Location:309 → 579
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:319 → 357
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:115 → 143
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  5. NM_001198876.1 → NP_001185805.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    See identical proteins and their annotated locations for NP_001185805.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5; also called 1a.C) lacks multiple exons in the 5' coding region, compared to variant 1. Variant 5 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
    Source sequence(s)
    AK164437, BQ174310, BY065048
    Consensus CDS
    CCDS16112.1
    UniProtKB/Swiss-Prot
    O88487, Q3TGH7
    UniProtKB/TrEMBL
    A2BFF7, Q3UDA2
    Related
    ENSMUSP00000107766.2, ENSMUST00000112138.8
    Conserved Domains (4) summary
    COG2319
    Location:303 → 573
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:109 → 137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:313 → 351
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:253 → 572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_001198877.1 → NP_001185806.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

    See identical proteins and their annotated locations for NP_001185806.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6; also called 1b.D) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 6 encode the same protein (isoform 1).
    Source sequence(s)
    AK168730, BQ174310, BY226221, GU992211
    UniProtKB/TrEMBL
    D6Q0F5, Q3UDA2
    Conserved Domains (4) summary
    COG2319
    Location:346 → 616
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:152 → 180
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:356 → 394
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:397 → 622
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. NM_001198878.1 → NP_001185807.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001185807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7; also called 1b.E) differs in the 5' UTR and uses an alternate splice acceptor site in the 5' coding region, compared to variant 1. Variant 7 encodes a shorter isoform (2), compared to isoform 1. Variants 2 and 7 encode the same protein.
    Source sequence(s)
    AK164437, BQ174310, BY226221, GU992212
    UniProtKB/TrEMBL
    D6Q0F6, Q3UDA2
    Conserved Domains (4) summary
    COG2319
    Location:341 → 611
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:147 → 175
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:351 → 389
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:392 → 617
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. NM_001347173.1 → NP_001334102.1  cytoplasmic dynein 1 intermediate chain 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    BX284624, BX544878
    Consensus CDS
    CCDS84536.1
    UniProtKB/TrEMBL
    A2BFF9, Q3UDA2
    Related
    ENSMUSP00000107772.3, ENSMUST00000112144.9
    Conserved Domains (3) summary
    COG2319
    Location:329 → 599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339 → 377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135 → 163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  9. NM_010064.4 → NP_034194.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

    See identical proteins and their annotated locations for NP_034194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8; also called 1b.C) differs in the 5' UTR and lacks multiple exons in the 5' coding region, compared to variant 1. Variant 8 encodes a shorter isoform (5), compared to isoform 1. Variants 5 and 8 encode the same protein.
    Source sequence(s)
    AK168730, BQ174310, BY226221, GU992210
    Consensus CDS
    CCDS16112.1
    UniProtKB/Swiss-Prot
    O88487, Q3TGH7
    UniProtKB/TrEMBL
    A2BFF7, Q3UDA2
    Related
    ENSMUSP00000080410.6, ENSMUST00000081710.12
    Conserved Domains (4) summary
    COG2319
    Location:303 → 573
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:109 → 137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:313 → 351
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:253 → 572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    71041999..71093647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315319.3 → XP_017170808.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

    UniProtKB/TrEMBL
    A2BFF9, Q3UDA2
    Related
    ENSMUSP00000107768.2, ENSMUST00000112140.8
    Conserved Domains (3) summary
    COG2319
    Location:329 → 599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339 → 377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135 → 163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  2. XM_017315326.3 → XP_017170815.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

    UniProtKB/TrEMBL
    A2BFF8, Q3UDA2
    Related
    ENSMUSP00000107767.2, ENSMUST00000112139.8
    Conserved Domains (3) summary
    COG2319
    Location:303 → 573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313 → 351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109 → 137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  3. XM_017315324.3 → XP_017170813.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

    UniProtKB/TrEMBL
    Q3UDA2
    Conserved Domains (3) summary
    COG2319
    Location:323 → 593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333 → 371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129 → 157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  4. XM_006498678.4 → XP_006498741.1  cytoplasmic dynein 1 intermediate chain 2 isoform X5

    See identical proteins and their annotated locations for XP_006498741.1

    UniProtKB/TrEMBL
    D6Q0F7, Q3UDA2
    Conserved Domains (3) summary
    COG2319
    Location:309 → 579
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:319 → 357
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:115 → 143
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  5. XM_006498677.3 → XP_006498740.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

    See identical proteins and their annotated locations for XP_006498740.1

    UniProtKB/TrEMBL
    Q3TPJ8, Q3UDA2
    Related
    ENSMUSP00000097605.4, ENSMUST00000100028.10
    Conserved Domains (3) summary
    COG2319
    Location:323 → 593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333 → 371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129 → 157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  6. XM_006498679.4 → XP_006498742.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

    UniProtKB/TrEMBL
    A2BFF8, Q3UDA2
    Conserved Domains (3) summary
    COG2319
    Location:303 → 573
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:313 → 351
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:109 → 137
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  7. XM_006498676.3 → XP_006498739.1  cytoplasmic dynein 1 intermediate chain 2 isoform X2

    UniProtKB/TrEMBL
    A2BFF5, Q3UDA2
    Related
    ENSMUSP00000107764.2, ENSMUST00000112136.2
    Conserved Domains (3) summary
    COG2319
    Location:329 → 599
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:339 → 377
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:135 → 163
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  8. XM_030247156.2 → XP_030103016.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

    UniProtKB/TrEMBL
    Q3UDA2
    Conserved Domains (3) summary
    COG2319
    Location:309 → 579
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:319 → 357
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:115 → 143
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

  9. XM_030247151.2 → XP_030103011.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

    UniProtKB/TrEMBL
    Q3UDA2
    Conserved Domains (3) summary
    COG2319
    Location:323 → 593
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:333 → 371
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:129 → 157
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

RNA

  1. XR_004938034.1 RNA Sequence

  2. XR_004938032.1 RNA Sequence

  3. XR_004938033.1 RNA Sequence

  4. XR_004938035.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88487.1 GenPept UniProtKB/Swiss-Prot:O88487

Gene LinkOut

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