Dll1 delta like canonical Notch ligand 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dll1provided by MGI
Official Full Name: delta like canonical Notch ligand 1provided by MGI
Primary source: MGI:MGI:104659
See related: Ensembl:ENSMUSG00000014773 AllianceGenome:MGI:104659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Delta1
Summary: Enables Notch binding activity and scaffold protein binding activity. Involved in several processes, including animal organ development; negative regulation of cell differentiation; and regionalization. Acts upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of cell differentiation; and nephron tubule development. Located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 27.4), spleen adult (RPKM 17.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A2; 17 8.95 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (15587616..15597275, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (15367354..15376932, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.
Title: Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.
Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse.
Title: Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse.
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Title: Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
DLL1 orchestrates CD8(+) T cells to induce long-term vascular normalization and tumor regression.
Title: DLL1 orchestrates CD8(+) T cells to induce long-term vascular normalization and tumor regression.
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Title: Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal.
Title: Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal.
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.
Title: Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.
Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.
Title: Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.
Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.
Title: Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.
Mice with CD11c lineage-specific deletion of Notch ligand gene Dll1, but not Jag2, exhibited accelerated growth of lung and pancreatic tumors concomitant with decreased antigen-specific CD8+T-cell functions and effector-memory (Tem) differentiation. Increased IL-4 but decreased IFN-gamma production and elevated populations of T-regulatory and myeloid-derived suppressor cells were observed in Dll1-ablated mice.
Title: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity.

Submit: New GeneRIF Correction See all GeneRIFs (102)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (25) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dll1 (e-PCR), detects polymorphism
- UniSTS:142853

NoName (e-PCR)
- UniSTS:237573

Dll1 (e-PCR), detects polymorphism
- UniSTS:142854

Dll1 (e-PCR), detects polymorphism
- UniSTS:259601

PMC281641P2 (e-PCR)
- UniSTS:272405

NoName (e-PCR)
- UniSTS:548389

Dll1 (e-PCR), detects polymorphism
- UniSTS:465447

UniSTS:465448 (e-PCR)
- UniSTS:465448

Dll1 (e-PCR), detects polymorphism
- UniSTS:465448

NoName (e-PCR)
- UniSTS:548161

Dll1 (e-PCR), detects polymorphism
- UniSTS:545925

Dll1 (e-PCR), detects polymorphism
- UniSTS:526072

NoName (e-PCR)
- UniSTS:225019

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in astrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auditory receptor cell fate commitment	NAS Non-traceable Author Statement more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebellar Purkinje cell layer structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar molecular layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within compartment pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial tip cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hemocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in in utero embryonic development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear auditory receptor cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in lateral inhibition	IDA Inferred from Direct Assay more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in left/right axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in loop of Henle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in marginal zone B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of hemocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of neuroepithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis of dentin-containing tooth	NAS Non-traceable Author Statement more info	PubMed
involved_in organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of skeletal muscle tissue growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: delta-like protein 1

Names: delta like-1; delta-like 1; drosophila Delta homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379042.1 → NP_001365971.1 delta-like protein 1 precursor

Status: VALIDATED

Source sequence(s)

AC154378

UniProtKB/Swiss-Prot

Q61483, Q6PFV7

Conserved Domains (4) summary

smart00051
Location:158 → 220

DSL; delta serrate ligand

cd00054
Location:442 → 477

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:484 → 514

EGF; EGF-like domain

pfam07657
Location:22 → 91

MNNL; N-terminus of Notch ligand
NM_007865.3 → NP_031891.2 delta-like protein 1 precursor

See identical proteins and their annotated locations for NP_031891.2

Status: VALIDATED

Source sequence(s)

BC065063, BQ768900

Consensus CDS

CCDS37452.1

UniProtKB/Swiss-Prot

Q61483, Q6PFV7

Related

ENSMUSP00000014917.8, ENSMUST00000014917.8

Conserved Domains (4) summary

smart00051
Location:158 → 220

DSL; delta serrate ligand

cd00054
Location:442 → 477

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:484 → 514

EGF; EGF-like domain

pfam07657
Location:22 → 91

MNNL; N-terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

15587616..15597275 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160292.1 → XP_036016185.1 delta-like protein 1 isoform X1

Conserved Domains (4) summary

smart00051
Location:158 → 220

DSL; delta serrate ligand

cd00054
Location:442 → 477

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:484 → 514

EGF; EGF-like domain

pfam07657
Location:22 → 91

MNNL; N-terminus of Notch ligand
XM_011246267.3 → XP_011244569.1 delta-like protein 1 isoform X1

Conserved Domains (4) summary

smart00051
Location:158 → 220

DSL; delta serrate ligand

cd00054
Location:442 → 477

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:484 → 514

EGF; EGF-like domain

pfam07657
Location:22 → 91

MNNL; N-terminus of Notch ligand