Gadd45a growth arrest and DNA-damage-inducible 45 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gadd45aprovided by MGI
Official Full Name: growth arrest and DNA-damage-inducible 45 alphaprovided by MGI
Primary source: MGI:MGI:107799
See related: Ensembl:ENSMUSG00000036390 AllianceGenome:MGI:107799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ddit1; GADD45
Summary: Enables promoter-specific chromatin binding activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and negative regulation of peptidyl-serine phosphorylation of STAT protein. Acts upstream of or within centrosome cycle; negative regulation of protein kinase activity; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; sensory organ; and tibialis anterior. Used to study systemic lupus erythematosus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 73.1), liver E14 (RPKM 52.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 30.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (67012080..67014391, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (67035096..67037407, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer's Disease Hallmarks.
Title: Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer's Disease Hallmarks.
GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.
Title: GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.
Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.
Title: Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.
GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
Title: GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury.
Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
Title: Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.
Title: Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.
GADD45A induces neuropathic pain by activating P53 apoptosis pathway in mice.
Title: GADD45A induces neuropathic pain by activating P53 apoptosis pathway in mice.
Gadd45alpha is involved in regulating activity-dependent and exon-specific BDNF expression in postmitotic cortical neurons.
Title: Gadd45α is involved in regulating activity-dependent and exon-specific BDNF expression in postmitotic cortical neurons.
GADD45alpha drives brown adipose tissue formation through upregulating PPARgamma in mice.
Title: GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice.
Gene analyses identify high Pdyn and Il6 levels in the amygdala as indicative of enhanced nociceptive hypersensitivity and reveal an association between high Gadd45 expression and attenuated emotional and cognitive manifestations of neuropathic pain.
Title: Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548380

U00937 (e-PCR)
- UniSTS:125638

Gadd45a (e-PCR), detects polymorphism
- UniSTS:546777

Gadd45a (e-PCR), detects polymorphism
- UniSTS:546778

Gadd45a (e-PCR), detects polymorphism
- UniSTS:142839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within centrosome cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: growth arrest and DNA damage-inducible protein GADD45 alpha

Names: DDIT-1; DNA damage-inducible transcript 1 protein; DNA-damage-inducible transcript 1; Gadd45alpha; growth arrest and DNA-damage-inducible, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007836.1 → NP_031862.1 growth arrest and DNA damage-inducible protein GADD45 alpha

See identical proteins and their annotated locations for NP_031862.1

Status: VALIDATED

Source sequence(s)

L28177

Consensus CDS

CCDS20217.1

UniProtKB/Swiss-Prot

P48316

UniProtKB/TrEMBL

Q3UMH6

Related

ENSMUSP00000044034.7, ENSMUST00000043098.9

Conserved Domains (1) summary

pfam01248
Location:21 → 105

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family