Dct dopachrome tautomerase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctprovided by MGI
Official Full Name: dopachrome tautomeraseprovided by MGI
Primary source: MGI:MGI:102563
See related: Ensembl:ENSMUSG00000022129 AllianceGenome:MGI:102563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DT; slt; TRP2; TRP-2; Tyrp2; slaty; Tyrp-2
Summary: Enables dopachrome isomerase activity. Involved in melanin biosynthetic process from tyrosine. Acts upstream of or within several processes, including developmental pigmentation; generation of neurons; and melanin biosynthetic process. Located in cytosol and melanosome. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; integumental system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 7.8), CNS E14 (RPKM 2.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E4; 14 61.6 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (118250202..118289658, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (118012790..118052246, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Dct(-/-) Mouse Model to Unravel Retinogenesis Misregulation in Patients with Albinism.
Title: The Dct(-/-) Mouse Model to Unravel Retinogenesis Misregulation in Patients with Albinism.
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
Title: MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
soyasaponin Ag inhibited TRP2 expression in a dosedependent manner. Therefore, the depigmenting effect of soyasaponin Ag may be due to the inhibition of tyrosinase expression or the enhancement of tyrosinase degradation.
Title: Soyasaponin Ag inhibits α‑MSH‑induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP‑2.
MIF-2/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4-dependent mechanisms.
Title: MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.
the slaty mutant melanocytes seem to be more sensitive to ultraviolet rays and oxidative stress than black melanocytes.
Title: The slaty (slt/Dct(slt) ) allele decreases the content of eumelanin, but not pheomelanin in the mouse hair.
A novel murine model of vitiligo is established by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide.
Title: Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo.
study indicates that tumor antigen (TRP2) expressed in MCMV induces a strong and long-lasting anti-melanoma effect through an antibody-dependent mechanism
Title: Cytomegalovirus-based cancer vaccines expressing TRP2 induce rejection of melanoma in mice.
Vaccine formulations with synthetic long peptides for treating B16F10 skin melanoma fails to elicit strong CD8 T cell responses to self-differentiation antigens TRP-2 and gp100.
Title: Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma.
level of gene targeting was not improved by the DSB induction, indicating a limited capacity of I-SceI to mediate homologous recombination at the Dct locus
Title: I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells.
Recombinant dopachrome tautomerase was expressed and purified, without its carboxy-terminal transmembrane region. Analysis of dopachrome tautomerase tryptic peptides by MALDI-TOF/TOF determined N-glycosylation as a primary post-translational modification.
Title: Purification and N-glycosylation analysis of melanoma antigen dopachrome tautomerase.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (4) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dopachrome isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopachrome isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables dopachrome isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanin biosynthetic process from tyrosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanin biosynthetic process from tyrosine	IDA Inferred from Direct Assay more info	PubMed
involved_in melanin biosynthetic process from tyrosine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to blue light	ISO Inferred from Sequence Orthology more info
involved_in ventricular zone neuroblast division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular zone neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: L-dopachrome tautomerase

Names: DOPAchrome conversion factor; DOPAchrome isomerase; DOPAchrome oxidoreductase; L-dopachrome Delta-isomerase; SLATY locus protein; tyrosinase-related protein 2

NP_034154.2

EC 5.3.3.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.