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Dapk3 death-associated protein kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 13144, updated on 21-Apr-2024

Summary

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Official Symbol
Dapk3provided by MGI
Official Full Name
death-associated protein kinase 3provided by MGI
Primary source
MGI:MGI:1203520
See related
Ensembl:ENSMUSG00000034974 AllianceGenome:MGI:1203520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dlk; ZIPK
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including cellular response to interferon-gamma; regulation of cell shape; and regulation of myosin II filament organization. Acts upstream of or within apoptotic signaling pathway. Located in PML body. Is expressed in heart; mammary gland epithelium; and notochord. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 67.6), duodenum adult (RPKM 59.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81018821..81029031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81182987..81193197)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene STARR-positive B cell enhancer ABC_E901 Neighboring gene STARR-positive B cell enhancer ABC_E8866 Neighboring gene STARR-positive B cell enhancer ABC_E3901 Neighboring gene STARR-positive B cell enhancer ABC_E5157 Neighboring gene STARR-positive B cell enhancer ABC_E2329 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2 Neighboring gene ataxia, cerebellar, Cayman type

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation-dependent control of ZIPK nuclear import is species specific. Weitzel DH, et al. Cell Signal, 2011 Jan. PMID 20854903, Free PMC Article
  2. Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK). Chang AN, et al. J Biol Chem, 2010 Feb 19. PMID 20038585, Free PMC Article
  3. Physical and functional interactions between STAT3 and ZIP kinase. Sato N, et al. Int Immunol, 2005 Dec. PMID 16219639
  4. ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts. Komatsu S, et al. J Cell Biol, 2004 Apr 26. PMID 15096528, Free PMC Article
  5. DAPK3 suppresses acini morphogenesis and is required for mouse development. Kocher BA, et al. Mol Cancer Res, 2015 Feb. PMID 25304685, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of ZIP kinase in development of myofibroblast differentiation from HPMCs.
    Title: Role of ZIP kinase in development of myofibroblast differentiation from HPMCs.
  2. The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway.
    Title: The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway.
  3. The induced deletion of Zipk significantly inhibited ischemia-reperfusion-induced blood-brain barrier dysfunction and neuronal injuries from middle cerebral artery occlusion and reperfusion, as evidenced by reduced infarct and edema volume, attenuated Evans blue dye leakage, and improved neuronal behavior.
    Title: ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury.
  4. Cellular and mouse modeling studies show that DAPK3 is a tumor suppressor gene and is important in early development.
    Title: DAPK3 suppresses acini morphogenesis and is required for mouse development.
  5. DAPK3 plays a central role in preventing miR-17/miR-20a depletion-induced genome instability and in miR-17/miR-20a overexpression-triggered tumor formation.
    Title: Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.
  6. The C-terminal domain (NLS2 motif)of ZIPK of murine is nonfunctional for transport.
    Title: Phosphorylation-dependent control of ZIPK nuclear import is species specific.
  7. ZIPK may act as a cardiac RLC kinase and thereby affect contractility.
    Title: Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK).
  8. murine ZIPK underwent specific divergence from a conserved consensus
    Title: ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to type II interferon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myosin II filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
death-associated protein kinase 3
Names
DAP kinase 3
DAP-like kinase
MYPT1 kinase
ZIP-kinase
death-associated kinase 3
NP_001177402.1
NP_001177403.2
NP_031854.1
XP_006513257.1
XP_006513258.1
XP_030100726.1
XP_036011469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190473.2 → NP_001177402.1  death-associated protein kinase 3 isoform b

    See identical proteins and their annotated locations for NP_001177402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24045.1
    UniProtKB/Swiss-Prot
    O54784
    UniProtKB/TrEMBL
    Q05A21
    Related
    ENSMUSP00000035962.7, ENSMUST00000047665.7
    Conserved Domains (1) summary
    cd14105
    Location:7 → 275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

  2. NM_001190474.2 → NP_001177403.2  death-associated protein kinase 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC155932
    Conserved Domains (2) summary
    smart00220
    Location:30 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14105
    Location:24 → 292
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

  3. NM_001428451.1 → NP_001415380.1  death-associated protein kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    O54784
    UniProtKB/TrEMBL
    Q05A21

  4. NM_001428452.1 → NP_001415381.1  death-associated protein kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC155932

  5. NM_007828.3 → NP_031854.1  death-associated protein kinase 3 isoform b

    See identical proteins and their annotated locations for NP_031854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24045.1
    UniProtKB/Swiss-Prot
    O54784
    UniProtKB/TrEMBL
    Q05A21
    Related
    ENSMUSP00000151577.2, ENSMUST00000219850.2
    Conserved Domains (1) summary
    cd14105
    Location:7 → 275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81018821..81029031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513194.2 → XP_006513257.1  death-associated protein kinase 3 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:24 → 285
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030244866.1 → XP_030100726.1  death-associated protein kinase 3 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:7 → 268
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006513195.4 → XP_006513258.1  death-associated protein kinase 3 isoform X2

    Conserved Domains (1) summary
    cd14105
    Location:7 → 275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

  4. XM_036155576.1 → XP_036011469.1  death-associated protein kinase 3 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:7 → 268
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54784.1 GenPept UniProtKB/Swiss-Prot:O54784

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