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Ctss cathepsin S [ Mus musculus (house mouse) ]

Gene ID: 13040, updated on 5-Mar-2024

Summary

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Official Symbol
Ctssprovided by MGI
Official Full Name
cathepsin Sprovided by MGI
Primary source
MGI:MGI:107341
See related
Ensembl:ENSMUSG00000038642 AllianceGenome:MGI:107341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cats
Summary
This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]
Expression
Broad expression in spleen adult (RPKM 32.7), large intestine adult (RPKM 28.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Ctss in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95434097..95463716)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95526786..95556405)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95315769-95315952 Neighboring gene cathepsin K Neighboring gene STARR-positive B cell enhancer ABC_E7927 Neighboring gene predicted gene, 40096 Neighboring gene high mobility group box 1, pseudogene 5 Neighboring gene HORMA domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95392515-95392816 Neighboring gene predicted gene, 40097 Neighboring gene golgi phosphoprotein 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cathepsin S deficiency improves muscle mass loss and dysfunction via the modulation of protein metabolism in mice under pathological stress conditions. Wan Y, et al. FASEB J, 2023 Aug. PMID 37428652
  2. Single-cell RNA sequencing of peripheral blood reveals that monocytes with high cathepsin S expression aggravate cerebral ischemia-reperfusion injury. Xie L, et al. Brain Behav Immun, 2023 Jan. PMID 36371010
  3. Circulating cathepsin S improves glycaemic control in mice. Karimkhanloo H, et al. J Endocrinol, 2021 Feb. PMID 33289685
  4. Cathepsin S-Mediated Negative Regulation of Wnt5a/SC35 Activation Contributes to Ischemia-Induced Neovascularization in Aged Mice. Xu W, et al. Circ J, 2019 Nov 25. PMID 31645525
  5. Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice. Wang H, et al. J Am Heart Assoc, 2019 Jul 16. PMID 31296090, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS.
    Title: Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS.
  2. Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
    Title: Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
  3. Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice.
    Title: Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice.
  4. Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.
    Title: Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.
  5. Cathepsin S deficiency improves muscle mass loss and dysfunction via the modulation of protein metabolism in mice under pathological stress conditions.
    Title: Cathepsin S deficiency improves muscle mass loss and dysfunction via the modulation of protein metabolism in mice under pathological stress conditions.
  6. Single-cell RNA sequencing of peripheral blood reveals that monocytes with high cathepsin S expression aggravate cerebral ischemia-reperfusion injury.
    Title: Single-cell RNA sequencing of peripheral blood reveals that monocytes with high cathepsin S expression aggravate cerebral ischemia-reperfusion injury.
  7. Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis.
    Title: Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis.
  8. Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells.
    Title: Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells.
  9. Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy.
    Title: Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy.
  10. Circulating cathepsin S improves glycaemic control in mice.
    Title: Circulating cathepsin S improves glycaemic control in mice.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proteoglycan binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of peptide antigen ISO
Inferred from Sequence Orthology
more info
  
involved_in basement membrane disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basement membrane disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in bone resorption ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome lumen TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cathepsin S
Names
Cat S
NP_001254624.2
NP_067256.4
XP_006501038.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267695.2 → NP_001254624.2  cathepsin S isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092203, AK028366, AK150274, BB072817
    Consensus CDS
    CCDS71291.1
    UniProtKB/TrEMBL
    F6WR04, Q3UD32
    Related
    ENSMUSP00000015667.4, ENSMUST00000015667.9
    Conserved Domains (2) summary
    smart00848
    Location:37 → 96
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:124 → 339
    Peptidase_C1; Papain family cysteine protease

  2. NM_021281.3 → NP_067256.4  cathepsin S isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_067256.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AK028366, BB072817
    Consensus CDS
    CCDS50992.1
    UniProtKB/Swiss-Prot
    E9QK18, O54973, O70370
    UniProtKB/TrEMBL
    Q8BSZ5, Q99M14
    Related
    ENSMUSP00000112006.3, ENSMUST00000116304.3
    Conserved Domains (2) summary
    smart00848
    Location:36 → 95
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:123 → 338
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95434097..95463716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500975.4 → XP_006501038.2  cathepsin S isoform X1

    UniProtKB/TrEMBL
    Q3U5K1
    Conserved Domains (1) summary
    pfam00112
    Location:42 → 257
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70370.2 GenPept UniProtKB/Swiss-Prot:O70370

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