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Cryz crystallin, zeta [ Mus musculus (house mouse) ]

Gene ID: 12972, updated on 5-Mar-2024

Summary

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Official Symbol
Cryzprovided by MGI
Official Full Name
crystallin, zetaprovided by MGI
Primary source
MGI:MGI:88527
See related
Ensembl:ENSMUSG00000028199 AllianceGenome:MGI:88527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sez9
Summary
Predicted to enable several functions, including NADPH binding activity; NADPH:quinone reductase activity; and mRNA 3'-UTR binding activity. Predicted to be involved in protein homotetramerization and xenobiotic catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human CRYZ (crystallin zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 72.1), placenta adult (RPKM 16.5) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Cryz in Genome Data Viewer
Location:
3 H4; 3 79.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (154302348..154328819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (154596711..154623182)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09339 Neighboring gene predicted gene, 40186 Neighboring gene STARR-positive B cell enhancer ABC_E9581 Neighboring gene STARR-seq mESC enhancer starr_09341 Neighboring gene tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E4607 Neighboring gene STARR-seq mESC enhancer starr_09345 Neighboring gene STARR-seq mESC enhancer starr_09346 Neighboring gene predicted gene 20389 Neighboring gene glutamate rich 3 Neighboring gene TNNI3 interacting kinase Neighboring gene STARR-seq mESC enhancer starr_09349 Neighboring gene leucine rich repeat containing 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability. Szutkowska M, et al. Kidney Int, 2009 Oct. PMID 19657324
  2. Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. Gonzalez P, et al. Mol Biol Evol, 1994 Mar. PMID 8170370
  3. Recruitment of enzymes as lens structural proteins. Wistow G, et al. Science, 1987 Jun 19. PMID 3589669
  4. Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells. Alam G, et al. Pflugers Arch, 2020 Nov. PMID 32914211
  5. Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. Rao PV, et al. Biochemistry, 1997 May 6. PMID 9154917

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.
    Title: Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.
  2. induction of zeta-crystallin by an acid pH plays an important role in preventing BSC1 mRNA decay
    Title: Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH:quinone reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH:quinone reductase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
quinone oxidoreductase
Names
NADPH:quinone reductase
quinone reductase
zeta-crystallin
NP_001344601.1
NP_001344602.1
NP_001344603.1
NP_001344604.1
NP_001344605.1
NP_034098.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357672.1 → NP_001344601.1  quinone oxidoreductase

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076
    Consensus CDS
    CCDS17927.1
    UniProtKB/Swiss-Prot
    P47199, Q62508, Q99L63
    UniProtKB/TrEMBL
    Q3UYY0, Q80XR3
    Conserved Domains (1) summary
    cd08253
    Location:8 → 331
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

  2. NM_001357673.1 → NP_001344602.1  quinone oxidoreductase

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076
    Consensus CDS
    CCDS17927.1
    UniProtKB/Swiss-Prot
    P47199, Q62508, Q99L63
    UniProtKB/TrEMBL
    Q3UYY0, Q80XR3
    Conserved Domains (1) summary
    cd08253
    Location:8 → 331
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

  3. NM_001357674.1 → NP_001344603.1  quinone oxidoreductase

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076
    Consensus CDS
    CCDS17927.1
    UniProtKB/Swiss-Prot
    P47199, Q62508, Q99L63
    UniProtKB/TrEMBL
    Q3UYY0, Q80XR3
    Conserved Domains (1) summary
    cd08253
    Location:8 → 331
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

  4. NM_001357675.1 → NP_001344604.1  quinone oxidoreductase

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076
    Consensus CDS
    CCDS17927.1
    UniProtKB/Swiss-Prot
    P47199, Q62508, Q99L63
    UniProtKB/TrEMBL
    Q3UYY0, Q80XR3
    Conserved Domains (1) summary
    cd08253
    Location:8 → 331
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

  5. NM_001357676.1 → NP_001344605.1  quinone oxidoreductase

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076
    Consensus CDS
    CCDS17927.1
    UniProtKB/Swiss-Prot
    P47199, Q62508, Q99L63
    UniProtKB/TrEMBL
    Q3UYY0, Q80XR3
    Conserved Domains (1) summary
    cd08253
    Location:8 → 331
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

  6. NM_009968.4 → NP_034098.1  quinone oxidoreductase

    See identical proteins and their annotated locations for NP_034098.1

    Status: VALIDATED

    Source sequence(s)
    AK134281, BB618817, BC043076
    Consensus CDS
    CCDS17927.1
    UniProtKB/Swiss-Prot
    P47199, Q62508, Q99L63
    UniProtKB/TrEMBL
    Q3UYY0, Q80XR3
    Related
    ENSMUSP00000029850.9, ENSMUST00000029850.15
    Conserved Domains (1) summary
    cd08253
    Location:8 → 331
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

RNA

  1. NR_151773.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076

  2. NR_151774.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107667, AC164292, BC043076

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    154302348..154328819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47199.1 GenPept UniProtKB/Swiss-Prot:P47199

Gene LinkOut

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