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Cradd CASP2 and RIPK1 domain containing adaptor with death domain [ Mus musculus (house mouse) ]

Gene ID: 12905, updated on 16-Apr-2024

Summary

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Official Symbol
Craddprovided by MGI
Official Full Name
CASP2 and RIPK1 domain containing adaptor with death domainprovided by MGI
Primary source
MGI:MGI:1336168
See related
Ensembl:ENSMUSG00000045867 AllianceGenome:MGI:1336168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAIDD
Summary
Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 6.7), adrenal adult (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 49.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95010601..95160000, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95174739..95324138, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9348 Neighboring gene predicted gene, 40744 Neighboring gene STARR-seq mESC enhancer starr_27609 Neighboring gene STARR-seq mESC enhancer starr_27611 Neighboring gene predicted gene, 53600 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94613739-94614040 Neighboring gene predicted gene, 29684 Neighboring gene STARR-seq mESC enhancer starr_27617 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94720661-94720962 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94723743-94724044 Neighboring gene STARR-seq mESC enhancer starr_27622 Neighboring gene STARR-positive B cell enhancer ABC_E6911 Neighboring gene STARR-seq mESC enhancer starr_27628 Neighboring gene RIKEN cDNA 2310039L15 gene Neighboring gene STARR-seq mESC enhancer starr_27629 Neighboring gene STARR-seq mESC enhancer starr_27631 Neighboring gene STARR-positive B cell enhancer ABC_E3909 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94834542-94834843 Neighboring gene STARR-seq mESC enhancer starr_27632 Neighboring gene STARR-positive B cell enhancer ABC_E5173 Neighboring gene suppressor of cytokine signaling 2 Neighboring gene predicted gene, 33230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer. Shen Q, et al. Am J Transl Res, 2014. PMID 25360218, Free PMC Article
  2. The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. Qiao H, et al. J Biol Chem, 2014 Aug 8. PMID 24958727, Free PMC Article
  3. In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos. Motaln H, et al. Transgenic Res, 2005 Feb. PMID 15865046
  4. Overexpression of Raidd cDNA inhibits differentiation of mouse preadipocytes. Felmer R, et al. Cell Prolif, 2003 Feb. PMID 12558660, Free PMC Article
  5. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Kim JY, et al. Cell Metab, 2022 Oct 4. PMID 36041455, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd
    Title: The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
  2. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists
    Title: The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.
  3. Neuronal caspase-2-dependent execution of neurons requires recptor-interacting protein RAIDD, not p53-inducible protein with a death domain (PIDD).
    Title: Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
  4. We show that CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1
    Title: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
  5. P53-induced protein with a death domain -induced apoptosis and growth suppression in embryonic fibroblasts depend on the adaptor protein receptor-interacting protein (RIP)-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD).
    Title: Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
  6. Overexpression of Raidd cDNA in 3T3L1 cells inhibited differentiation of the preadipocytes.
    Title: Overexpression of Raidd cDNA inhibits differentiation of mouse preadipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables death domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of endopeptidase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
death domain-containing protein CRADD
Names
RIP-associated protein with a death domain
caspase and RIP adapter with death domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330138.1 → NP_001317067.1  death domain-containing protein CRADD

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AA109538, AC153940, AI430259, BE991734, BQ571215
    Consensus CDS
    CCDS24135.1
    UniProtKB/Swiss-Prot
    O88843, Q9QUN0
    UniProtKB/TrEMBL
    Q549T4
    Related
    ENSMUSP00000151735.2, ENSMUST00000217809.2
    Conserved Domains (2) summary
    cd08319
    Location:116 → 198
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  2. NM_001330141.1 → NP_001317070.1  death domain-containing protein CRADD

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AA109538, AC153366, AC153940, AV581600, BE991734
    Consensus CDS
    CCDS24135.1
    UniProtKB/Swiss-Prot
    O88843, Q9QUN0
    UniProtKB/TrEMBL
    Q549T4
    Conserved Domains (2) summary
    cd08319
    Location:116 → 198
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  3. NM_001330175.1 → NP_001317104.1  death domain-containing protein CRADD

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AA109538, AC153366, AC153940, AI426523, BE991734
    Consensus CDS
    CCDS24135.1
    UniProtKB/Swiss-Prot
    O88843, Q9QUN0
    UniProtKB/TrEMBL
    Q549T4
    Conserved Domains (2) summary
    cd08319
    Location:116 → 198
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  4. NM_009950.3 → NP_034080.1  death domain-containing protein CRADD

    See identical proteins and their annotated locations for NP_034080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AA109538, AC153366, AC153940, AK163112, BE991734
    Consensus CDS
    CCDS24135.1
    UniProtKB/Swiss-Prot
    O88843, Q9QUN0
    UniProtKB/TrEMBL
    Q549T4
    Related
    ENSMUSP00000050295.6, ENSMUST00000053594.7
    Conserved Domains (2) summary
    cd08319
    Location:116 → 198
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95010601..95160000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513180.2 → XP_006513243.1  death domain-containing protein CRADD isoform X1

    See identical proteins and their annotated locations for XP_006513243.1

    UniProtKB/Swiss-Prot
    O88843, Q9QUN0
    UniProtKB/TrEMBL
    Q549T4
    Related
    ENSMUSP00000152022.2, ENSMUST00000220279.2
    Conserved Domains (2) summary
    cd08319
    Location:116 → 198
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  2. XM_006513181.4 → XP_006513244.1  death domain-containing protein CRADD isoform X1

    See identical proteins and their annotated locations for XP_006513244.1

    UniProtKB/Swiss-Prot
    O88843, Q9QUN0
    UniProtKB/TrEMBL
    Q549T4
    Conserved Domains (2) summary
    cd08319
    Location:116 → 198
    Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  3. XM_030244859.2 → XP_030100719.1  death domain-containing protein CRADD isoform X2

    UniProtKB/TrEMBL
    Q3UMW0
    Conserved Domains (1) summary
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  4. XM_006513184.5 → XP_006513247.1  death domain-containing protein CRADD isoform X2

    See identical proteins and their annotated locations for XP_006513247.1

    UniProtKB/TrEMBL
    Q3UMW0
    Conserved Domains (1) summary
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

  5. XM_006513183.5 → XP_006513246.1  death domain-containing protein CRADD isoform X2

    See identical proteins and their annotated locations for XP_006513246.1

    UniProtKB/TrEMBL
    Q3UMW0
    Conserved Domains (1) summary
    cd08327
    Location:1 → 94
    CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88843.2 GenPept UniProtKB/Swiss-Prot:O88843

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