U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC128926495 STARR-positive B cell enhancer ABC_E194 [ Mus musculus (house mouse) ]

Gene ID: 128926495, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Gene symbol
LOC128926495
Gene description
STARR-positive B cell enhancer ABC_E194
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr369100
Summary
This genomic region includes a B cell regulatory element that was identified by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing). It was validated as an enhancer by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. Two subregions were identified as candidate cis-regulatory modules (CRMs) in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. They were validated as enhancers by CapStarr-seq reporter assays showing weak activity in P5424 T cells and NIH3T3 fibroblasts. [provided by RefSeq, Sep 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128138973..128139322)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127740631-127740818 Neighboring gene predicted gene, 23241 Neighboring gene PAN2 poly(A) specific ribonuclease subunit Neighboring gene canopy FGF signaling regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Vanhille L, et al. Nat Commun, 2015 Apr 15. PMID 25872643

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Other Names

  • CapStarr-seq enhancer MGSCv37_chr10:127740160-127740343
  • CapStarr-seq enhancer MGSCv37_chr10:127740400-127740509
  • regulatory region 369100

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_152147.2 

    Range
    101..450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128138973..128139322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version