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SIRPD signal regulatory protein delta [ Homo sapiens (human) ]

Gene ID: 128646, updated on 5-Mar-2024

Summary

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Official Symbol
SIRPDprovided by HGNC
Official Full Name
signal regulatory protein deltaprovided by HGNC
Primary source
HGNC:HGNC:16248
See related
Ensembl:ENSG00000125900 AllianceGenome:HGNC:16248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPNS1L2; dJ576H24.4
Summary
Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 26.7) See more
Orthologs
all
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Genomic context

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Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1534251..1557705, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1583429..1606887, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1514897..1538351, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372499 Neighboring gene uncharacterized LOC105372498 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1501740-1502939 Neighboring gene RNA, U6 small nuclear 917, pseudogene Neighboring gene uncharacterized LOC107985409 Neighboring gene signal regulatory protein beta 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:1615736-1616561 Neighboring gene SIRPG antisense RNA 1 Neighboring gene signal regulatory protein gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A nomenclature for signal regulatory protein family members. van den Berg TK, et al. J Immunol, 2005 Dec 15. PMID 16339511
  2. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
  3. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
signal-regulatory protein delta
Names
SIRP-delta
protein tyrosine phosphatase, non-receptor type substrate 1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410802.1 → NP_001397731.1  signal-regulatory protein delta isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL049634
    Consensus CDS
    CCDS93001.1
    UniProtKB/TrEMBL
    Q5TFQ5
    Related
    ENSP00000371034.1, ENST00000381621.5

  2. NM_178460.3 → NP_848555.2  signal-regulatory protein delta isoform 1 precursor

    See identical proteins and their annotated locations for NP_848555.2

    Status: VALIDATED

    Source sequence(s)
    AL049634, BC033502, DA466740
    Consensus CDS
    CCDS13018.1
    UniProtKB/Swiss-Prot
    B3KS88, Q5TFQ6, Q9H106
    Related
    ENSP00000371036.3, ENST00000381623.4
    Conserved Domains (2) summary
    smart00410
    Location:38 → 118
    IG_like; Immunoglobulin like
    pfam07686
    Location:34 → 140
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    1534251..1557705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439883.1 → XP_047295839.1  signal-regulatory protein delta isoform X1

  2. XM_047439887.1 → XP_047295843.1  signal-regulatory protein delta isoform X4

  3. XM_047439886.1 → XP_047295842.1  signal-regulatory protein delta isoform X3

  4. XM_047439885.1 → XP_047295841.1  signal-regulatory protein delta isoform X2

  5. XM_047439888.1 → XP_047295844.1  signal-regulatory protein delta isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    1583429..1606887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322961.1 → XP_054178936.1  signal-regulatory protein delta isoform X1

  2. XM_054322963.1 → XP_054178938.1  signal-regulatory protein delta isoform X3

  3. XM_054322962.1 → XP_054178937.1  signal-regulatory protein delta isoform X2

  4. XM_054322964.1 → XP_054178939.1  signal-regulatory protein delta isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H106.2 GenPept UniProtKB/Swiss-Prot:Q9H106

Gene LinkOut

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